甲状腺癌是一种少见的恶性肿瘤，它的发病率正在增加，最近的研究进展改进了对于甲状腺癌发病机理的理解。这些改变包括激活普通效应基因（包括RET–Ras–BRAF信号系统和其他独特的染色体重排）的遗传变化鉴定；作为发病机理，他们中的某些因素与射线照射有关联，转录因子和黏附分子转录后调节缺陷以及细胞周期控制元件似乎都影响肿瘤发展。这些信息能提供有力的辅助诊断工具，而且也能用来鉴别新的治疗靶点。
原文出处：Review
英文题目:Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Nature Reviews Cancer 6, 292-306 (April 2006) | doi:10.1038/nrc1836
Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Tetsuo Kondo1,2, Shereen Ezzat2,3 and Sylvia L. Asa1,2 About the author
Top of pageAbstractThyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET–Ras–BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
