生物谷报道：朊病毒越来越被发现具有多种特殊的生理和病理功能，而且不仅仅是在神经系统中发挥作用。最新一期FASEB J杂志报道了中国第四军医大学樊代明教授最新研究成果：朊病毒能促进胃肠癌症的侵袭和转移！这一研究首次提出朊病毒在肿瘤中的扮演的角色。同时进一步发现MEK信号，以及其下游的MMP11在这一过程参与了重要角色。
原始出处：
Yanglin Pan, Lina Zhao, Jie Liang, Jie Liu, Yongquan Shi, Na Liu, Guoyun Zhang, Haifeng Jin, Juan Gao, Huahong Xie, Jun Wang, Zhiguo Liu, and Daiming Fan
Cellular prion protein promotes invasion and metastasis of gastric cancer
FASEB J. 2006 20: 1886-1888. Published in Advance July 28, 2006, 10.1096/fj.06-6138fje [Abstract] [Full Text] [PDF] [Summary]
英文摘要：
Cellular prion protein (PrPc) is a glycosylphosphatidylinositol (GPI) -anchored membrane protein that is highly conserved in mammalian species. PrPc has the characteristics of adhesive molecules and is thought to play a role in cell adhesion and membrane signaling. Here we investigated the possible role of PrPc in the process of invasiveness and metastasis in gastric cancers. PrPc was found to be highly expressed in metastatic gastric cancers compared to nonmetastatic ones by immunohistochemical staining. PrPc significantly promoted the adhesive, invasive, and in vivo metastatic abilities of gastric cancer cell lines SGC7901 and MKN45. PrPc also increased promoter activity and the expression of MMP11 by activating phosphorylated ErK1/2 in gastric cancer cells. MEK inhibitor PD98059 and MMP11 antibody (Ab) significantly inhibited in vitro invasive and in vivo metastatic abilities induced by PrPc. N-terminal fragment (amino acid 24–90) was suggested to be an indispensable region for signal transduction and invasion-promoting function of PrPc. Taken together, the present work revealed a novel function of PrPc that the existence of N-terminal region of PrPc could promote the invasive and metastatic abilities of gastric cancer cells at least partially through activation of MEK/ERK pathway and consequent transactivation of MMP11.—Pan, Y., Zhao, L., Liang, J., Liu, J., Shi, Y., Liu, N., Zhang, G., Jin, H., Gao, J., Xie, H., Wang, J., Liu, Z., Fan, D. Cellular prion protein promotes invasion and metastasis of gastric cancer.
有关朊病毒更多报道：
Science:朊病毒感染导致心脏损伤
朊病毒研究最新发现
北京猿人可能是早期食人族 朊病毒基因揭秘
科学家在土壤中发现朊病毒
朊病毒促进脑细胞的制造？
Nature：朊病毒传染性与蛋白分子大小有关
Nature Medicine：检测血液中的朊病毒新方法
研究人员确认朊病毒的三维结构
Nature：朊病毒和淀粉体的结构
变异的朊病毒蛋白可造成无症状感染
科学家首次观察到朊病毒入侵脑细胞的活动
Cell：科学家发现朊病毒铁证
研究发现朊病毒存在于被感染小鼠的其它器官
颇尔公司展示朊病毒消除技术
一些朊病毒疾病的特征与基因有关
英国发现新的羊瘙痒病 不排除为新型朊病毒
生物谷专题：朊病毒的纷争
朊病毒蛋白有两面性--增进记忆
科研人员最新研究发现RNA能够促进致病性朊病毒的形成
破解朊病毒
