生物谷报道:12月26日,路透通讯社健康版报道,妊娠早期循环中胰岛素样生长因子-1水平的升高可能会造成其得乳腺癌的风险增加,美国和瑞典研究者在12月份的《癌症流行病学,生物标记和预防》中这样报道。
纽约大学医学院的Annekatrin博士及其同事指出,尽管有大量的报道,但是IGF-1和乳腺癌的联系仍不明确。她和她的同事提出这样的假说:出现高IGF-1水平的妊娠早期,会有一段以乳腺细胞强烈增殖为特点的时期,可能会增加乳腺恶变的风险。为了进一步调查,研究者组织了一项包括212项病例及369项对照的研究。受试者妇女有部分是正在产科医院中生了单胞胎并在妊娠早期留有血样的产妇。乳腺癌的风险随着IGF-1水平的升高而增加,水平最高组与最低组之比为1.7。这种联系在初产妇组中(比率为2.2)比其他组中(比率为1.4)较强。而且,在有最高IGF-1水平的组中乳腺癌的风险随年龄增加而减小。比如,在年龄小于28岁的比率为2.5,而在年龄大于33岁的比率则为1.2。那些观察到乳腺癌的风险与IGF-2的水平无关的研究者们指出,他们正在设计一项更大的研究,其结果将在统计学上更加明确年龄在乳腺癌与IGF-1水平关系中的效应。
原文出处:
Insulin-Like Growth Factor May Be Tied to Breast Cancer
NEW YORK (Reuters Health) Dec 26 - Elevated levels of circulating insulin-like growth factor (IGF)-1 early in pregnancy appear to be associated with an increased risk of the development of breast cancer, US and Swedish researchers report in the December issue of Cancer Epidemiology, Biomarkers and Prevention.
Dr. Annekatrin Lukanova of New York University School of Medicine and colleagues note that despite numerous reports, the association of IGF-1 with breast cancer is unclear. She and her colleagues hypothesized that exposure to high IGF-1 in early pregnancy, "a period characterized by intense cell proliferation in the breasts," might increase the risk of breast malignancy.
To investigate further, the researchers conducted a study of 212 cases and 369 controls. The women were part of an ongoing maternity cohort who delivered singleton babies and had given blood samples early in pregnancy.
Breast cancer risk increased with increasing IGF-1 levels. For those with the highest levels compared with the lowest levels, the odds ratio was 1.7. The association was stronger in primiparas (odds ratio, 2.2) than in others (odds ratio, 1.4).
In addition, the risk in those with the highest IGF-1 levels appears to decrease with increasing age. For example, the odds ratio was 2.5 in those under the age of 28 years. The corresponding value was 1.2, in women over the age of 33 years.
The researchers, who observe that there was no association between cancer risk and levels of IGF-2, note that they are now planning a much larger study "which will have adequate statistical power to address the effect of age on the association of breast cancer with circulating IGF-1."
Cancer Epidemiol Biomarkers Prev 2006;15:2489-2493.