英国莱斯特大学(University of Leicester)的生医学家已在实验室证实米糠(rice bran)能降低肠癌的风险，但目前尚未进行人体试验，研究成果发表于British Journal of Cancer期刊。
Andreas Gescher教授说：「先前有许多研究已证实小麦与裸麦糠具有抗癌的特性，但此研究却是第一个证明米糠能抗癌的文献。」在实验室的预试验中，研究人员给予受试者每人每天大约200克的米糠食用量，比较了米糠对乳癌、前列腺癌及肠癌的效益，发现能降低51%的肠胃腺瘤细胞，而对乳癌、前列腺瘤细胞则没有抑制作用，研究人员指出：「米糠能降低肠癌的重点应该是米糠内的纤维成份，相信未来米糠对于结肠直肠癌的预防大有潜力。」
(资料来源 : Bio.com)
部分英文原文：
Translational Therapeutics
British Journal of Cancer (2007) 96, 248-254.
doi:10.1038/sj.bjc.6603539 www.bjcancer.com Published online 9 January 2007
Evaluation of the cancer chemopreventive efficacy of rice bran in genetic mouse models of breast, prostate and intestinal carcinogenesis
R D Verschoyle1, P Greaves1, H Cai1, R E Edwards2, W P Steward1 and A J Gescher1
1Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
2Medical Research Council Toxicology Unit, University of Leicester, Leicester, UK
Correspondence to: Professor AJ Gescher, E-mail: ag15@le.ac.uk
Revised 16 October 2006; accepted 20 November 2006; published online 9 January 2007
Brown rice is a staple dietary constituent in Asia, whereas rice consumed in the Western world is generally white, obtained from brown rice by removal of the bran. We tested the hypothesis that rice bran interferes with development of tumours in TAg, TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) or ApcMin mice, genetic models of mammary, prostate and intestinal carcinogenesis, respectively. Mice received rice bran (30%) in AIN-93G diet throughout their post-weaning lifespan. In TAg and TRAMP mice, rice bran did not affect carcinoma development. In TRAMP or wild-type C57Bl6/J mice, dietary rice bran increased kidney weight by 18 and 20%, respectively. Consumption of rice bran reduced numbers of intestinal adenomas in ApcMin mice by 51% (P<0.01), compared to mice on control diet. In parallel, dietary rice bran decreased intestinal haemorrhage in these mice, as reflected by increased haematocrit. At 10% in the diet, rice bran did not significantly retard ApcMin adenoma development. Likewise, low-fibre rice bran (30% in the diet) did not affect intestinal carcinogenesis, suggesting that the fibrous constituents of the bran mediate chemopreventive efficacy. The results suggest that rice bran might be beneficially evaluated as a putative chemopreventive intervention in humans with intestinal polyps.
Keywords: chemoprevention; diet; rice bran; genetic models of carcinogenesis
