生物谷报道：人类染色体8q24的突变可引发前列腺癌的发病风险。最近，研究人员证实了结肠直肠癌同样受到该类突变的调节。该研究结果发表在最新一期的《自然遗传学》杂志上。
研究人员研究了1807例受感染的病例和5511例正常人对照。结果显示，该类突变中的的一个叫做rs6983267的突变体和结肠直肠癌的发生有显著的关联性。研究结果还发现，该类突变中不同突变体引发两种癌症的风险分配也有显著差异。
这一研究结果证实了人类染色体8q24的突变体对癌症的发生具有明显的效应，并且该效应依赖于组织类型的不同而有差异。
Figure 1 - Fine mapping in the region 128.47–128.54 Mb of 8q24.
We present data for 82 SNPs that we genotyped in 1,088 individuals with CRC and 1,823 controls. These SNPs capture 92% of SNPs of >5% minor allele frequency at r2>0.8 in HapMap populations (Supplementary Fig. 2). (a) The most strongly associated SNP is rs10808556 (red), P = 2.2 10-6, which is substantially more associated than rs6983267 (green), the SNP that initially led us to the region (P = 2.4 10-4). (b) Controlling for rs10808556 in a logistic regression analysis, no SNP is significant at P < 0.05 after correcting for 82 hypotheses tested (threshold shown by a light gray line).
原文出处：
Nature Genetics August 2007, Volume 39 No 8
A common genetic risk factor for colorectal and prostate cancer - pp954 - 956
Christopher A Haiman, Loïc Le Marchand, Jennifer Yamamato, Daniel O Stram, Xin Sheng, Laurence N Kolonel, Anna H Wu, David Reich & Brian E Henderson
doi:10.1038/ng2098
Abstract | Full Text | PDF (140 KB) | Supplementary information
Haiman , Christopher
