生物谷报道：美国Roswell Park研究中心的科研人员在肿瘤综述杂志上提出新观点，维生素D信号通路是潜在的抗肿瘤治疗途径之一。
维生素D代谢通路：25（OH）D3被运至肾皮质部，被肾脏的25-羟基维生素D3 1α-羟化酶和24-羟化酶分别羟化为1，25（OH）2D3 和24，25（OH）2D3 。1，25（OH）2D3是生物活性最强的代谢物。
流行病学调查发现，人类多种肿瘤的病因与维生素D缺乏有关。临床前期研究也发现，活性维生素D（α25(OH)(2)D(3)，钙三醇）及维生素D类似物有抗肿瘤作用，抑制肿瘤细胞增殖，促进其调亡，及抑制血管生成。此外，钙三醇抗肿瘤效应还影响多种细胞毒素和抗肿瘤药物。
由此，研究者总结认为，从流行病学、试验及临床研究，都支持维生素D及维生素D类似物具有防治肿瘤的作用。
原始出处:
Nature Reviews Cancer 7, 684-700 (September 2007) | doi:10.1038/nrc2196
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics
Kristin K. Deeb1, Donald L. Trump2 & Candace S. Johnson1 About the authors
Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1,25(OH)2D3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1,25(OH)2D3 and vitamin D analogues as preventative and therapeutic anticancer agents.
Author affiliations
Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, USA.
Departments of Pharmacology and Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA.
Correspondence to: Candace S. Johnson1 Email: candace.johnson@roswellpark.org
