最新一期《美国肠胃病学杂志》（American Journal of Gastroenterology）公布的一份研究报告说，美国食道癌患者数量近年来急剧增加，肥胖是主要原因之一，因此避免肥胖有助于预防食道癌。
报告说，从1973年至2001年，美国的食道癌患者人数由30万人增加至210万人。尽管确切原因尚待进一步探讨，但研究显示，高脂肪、高糖饮食的过量摄取和因此导致的肥胖症，是诱发食道癌的主要因素之一。
报告指出，食道癌是人类常见的恶性肿瘤之一，治愈率较低。在美国，食道癌患者术后5年存活率不到20%。为了更好地预防食道癌，专家建议人们应该改掉不良饮食习惯，少食用高脂肪和高糖食品，增加运动，避免肥胖。（来源：新华网 高原）
生物谷推荐原始出处:
（American Journal of Gastroenterology），Volume 103 Issue 2 Page 292，Michael B. Cook，David Forman
A Systematic Review and Meta-Analysis of the Riskof Increasing Adiposity on Barrett's Esophagus
Michael B. Cook, B.Sc., Ph.D. , Darren C. Greenwood, B.Sc., M.Sc. , Laura J. Hardie, B.Sc., Ph.D. , Christopher P. Wild, B.Sc., Ph.D. 1, and David Forman, B.A., Ph.D.
OBJECTIVES: Esophageal adenocarcinoma and its precursor lesion, Barrett's esophagus, are increasing in incidence in western populations. Gastroesophageal reflux disease (GERD) and high body mass index (BMI) are known risk factors, but it is unclear whether BMI mediates its risk on Barrett's esophagus independently. This systematic review and meta-analysis investigated whether increasing BMI is associated with Barrett's esophagus as compared to general population and GERD controls.
METHODS: Search strategies were conducted in MEDLINE (U.S. National Library of Medicine, Bethesda, MD) (1966–2005) and EMBASE (Reed Elsevier PLC, Amsterdam, The Netherlands) (1980–2005). Studies to be included were required to present “current” BMI data for consecutively recruited Barrett's esophagus patients and appropriate comparison arms with a minimum number of 30 subjects in each.
RESULTS: The literature search produced 5,501 hits from which 295 papers were extracted. Only 10 studies met the criteria for inclusion. The Statistics/Data Analysis (STATA) program was used to conduct random effects meta-analyses. Nine studies comparing the BMI of the Barrett's esophagus and GERD groups produced a pooled odds ratio (OR) of 0.99 per kg/m2 (95% confidence interval [CI] 0.97–1.01, I2 = 52%), while the pooled estimate of three studies comparing Barrett's esophagus with general population controls was 1.02 per kg/m2 (95% CI 1.01–1.04, I2 = 0%).
CONCLUSIONS: Increasing adiposity is only an indirect risk factor of Barrett's esophagus through the precursor lesion of GERD. Hence, BMI status has no predictive value with respect to GERD patients and their risk of progression to Barrett's esophagus.
