2008年2月的爱思唯尔期刊《胃肠道内镜》(Gastrointestinal Endoscopy)刊登了日本自治医科大学的一项最新研究,研究表明采用最佳光谱显像(OBI)系统内镜能够有效地诊断出凹陷型早期胃癌。
胃癌是最常见的恶性肿瘤之一,胃癌的早期发现和早期诊断是及早治疗的基础,也是降低胃癌死亡率的关键一环。癌组织浸润仅限于粘膜层及粘膜下层者均属早期胃癌,判断早期胃癌的标准不是其面积大小而是其深度,故早期胃癌也称为粘膜内癌或表浅扩散性癌。早期胃癌经手术切除治疗,预后颇为良好,术后5年存活率可达90%。早期表浅型胃癌肿瘤表面较平坦,隆起不显著,其肉眼形态可分为3种类型:隆起型,平坦型和凹陷型(又名癌性糜烂)。与正常组织相比,凹陷型早期胃癌在颜色和形状上仅有微小变化,内窥镜诊断起来相对比较困难。
最新研究显示,最佳光谱显像(OBI)内镜系统能从普通内镜显像中重建出非常好的光谱影像,这种显像技术原理是基于通过应用光谱估算技术在算术上缩短常规图像的带宽。采用该系统诊断凹陷型早期胃癌,其分界线能很容易的通过不用放大的最佳光谱图像来识别,因为在内镜下能明显地观察到癌组织的淡红色图像和周围正常组织的淡黄色图像的清楚的分界。
研究人员认为,同传统的内镜系统相比,OBI系统在诊断凹陷型早期胃癌更为有效,具有广阔的发展和应用前景。(科学网 于乃森/编译)
生物谷推荐原始出处:
(Gastrointestinal Endoscopy),doi:10.1016/j.gie.2007.06.067,Hiroyuki Osawa, Kentaro Sugano
Optimal band imaging system can facilitate detection of changes in depressed-type early gastric cancer
Hiroyuki Osawa MD, Mitsuyo Yoshizawa MD, Hironori Yamamoto MD, Hiroto Kita MD, Kiichi Satoh MD, Hirohide Ohnishi MD, Hidetoshi Nakano MD, Masahiro Wada MD, Masayuki Arashiro MD, Mamiko Tsukui MD, Kenichi Ido MD and Kentaro Sugano MD
Background
The endoscopic diagnosis of depressed-type early gastric cancers is difficult because these cancers manifest as subtle changes in color and shape. The newly developed optimal band imaging (OBI) system can reconstruct the best spectral images derived from ordinary endoscopic images and enhances the mucosal surface without the use of dyes. This imaging technique is based on narrowing the bandwidth of conventional image arithmetically by using spectral estimation technology.
Objective
Evaluation of the usefulness of the OBI system for identifying the demarcation line of depressed-type early gastric cancers.
Design
Prospective study.
Setting
Jichi Medical University in Japan.
Patients
Twenty-seven cases with depressed-type early gastric cancer.
Main Outcome Measurement
Comparative study for the success rate of identifying the demarcation line of depressed-type early gastric cancer by using optimal band images and conventional endoscopic images.