生物谷报道:美国纽约Rochester大学的研究人员首次证实,一种存在于葡萄皮和红酒中的天然抗氧化物通过到达细胞的动力工程线粒体,能够帮助摧毁胰腺癌细胞。这项研究的结果发表在3月的Advances in Experimental Medicine and Biology杂志上。
研究还证实,当胰腺癌细胞受到抗氧化物质白藜芦醇和辐射的双重联合时,这种联合能诱导发生细胞死亡。
研究的领导者 Paul Okunieff, MD博士指出,这项研究对患者有多重意义,这项新研究显示,白藜芦醇不但能够到达所希望的靶标,而且还能破坏恶性细胞的连接,并且同时保护受害的正常组织不受放射的有害影响。
研究的领导者Paul Okunieff博士指出,这项研究对患者有多重意义,这项新研究显示,白藜芦醇不但能够到达所希望的靶标,而且还能破坏恶性细胞的连接,并且同时保护受害的正常组织不受放射的有害影响。
注:Rochester大学位于美国纽约州西部安大略湖南岸,是私立综合研究型大学,根据us news的综合排名为全美前四十名,其下所属的伊士曼音乐学院(eastman school of music)为全美最佳的音乐学院,以学理与演奏艺术兼重著称;赛门商业管理学院(simon graduate school of business administration)是全美前三十名的商学院;labortory for laser energetics拥有全球最大功率的雷射;而医学院亦有甚佳的风评,尤其在临床医学的表现;所附设置思壮纪念医院是纽约西部最大的医学中心。除此之外,光学,经济学,政治学,心理学等学科也都是著名的科系强项。罗切斯特理工学院则以大学本科教育与专精职业训练闻名,光学摄影与影像处理十分闻名。另设置了国家聋哑高等教育中心,是专供美国聋哑残障人士就学的高等教育机构。
英文原文链接:http://www.foodnavigator.com/news/ng.asp?n=84238-resveratrol-red-wine-cancer
生物谷推荐原始出处:
Advances in Experimental Medicine and Biology
2008;614:179-86
Anti-cancer effect of resveratrol is associated with induction of apoptosis via a mitochondrial pathway alignment
Authors: Paul Okunieff, Weimin Sun, Wei Wang, Jung Kim, Shanmin Yang
Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Resveratrol, a phytoalexin found in the skin of grapes, is believed to have multiple bioactivities including anti-cancer, anti-carcinogenesis and antiinflammatory. The mechanisms by which resveratrol might produce these effects are not well understood. In this study, malignant human pancreatic cancer cells were treated without or with resveratrol in combination with ionizing radiation (IR), and then the mitochondrial function of treated cells was evaluated using several standardized assays. They include the Calcein AM method for mitochondria transition pore; the JC-1 staining method for mitochondria membrane potential; the CM-H2DCFDA method for reactive oxygen species; and the Annexin V/propidium iodide (PI) method for apoptosis/cell death. Our results indicated that (1) pore function was partially intact after resveratrol, but resveratrol probably interfered with the accumulation of intracellular Calcein AM; (2) depolarization of the mitochondria membrane was increased in the resveratrol treated cells, consistent with mitochondrial dysfunction; (3) ROS was slightly increased with resveratrol, a phenomenon that was greatly increased when this agent was combined with IR; and (4) in parallel with the above changes in mitochondrial and drug transport, cells treated with resveratrol showed increased apoptosis as measured by Annexin V/PI staining. In summary, the anti-cancer effect of resveratrol is associated with the damage of mitochondrial function that leads to increased ROS, apoptosis, and possibly intracellular drug accumulation via inhibition of proteins involved in multi-drug resistance (MDR).
PMID: 18290328 [PubMed - in process]