生物谷讯：10月23日，乳腺癌研究领域专业杂志《乳腺癌研究和治疗》（Breast Cancer Research and Treatment）在线发表了中科院上海生命科学研究院营养所王慧研究员等的一项关于维生素D和钙的摄入量对女性乳腺癌风险关系的Meta-analysis研究成果。研究表明高水平的维生素D和钙的摄入能够显著降低女性患有乳腺癌的风险，血清中25-羟维生素D(25(OH)D)水平和患乳腺癌风险呈显著负相关，而血清中维生素D的活性形式1α,25-二羟维生素D（1α，25(OH)2D）水平和患乳腺癌风险无关。
研究发现，通过膳食或营养补充的高维生素D摄入人群比低摄入人群发生乳腺癌的风险显著降低9%（RR = 0.91，95% CI = 0.85-0.97）；血清中25(OH)D处于最高水平的女性患有乳腺癌的风险比血清中最低25(OH)D水平的女性低近45%（OR = 0.55, 95% CI = 0.38-0.80）；而血清中1α，25(OH)2D水平的高低和患乳腺癌风险没有关联（OR = 0.99，95% CI = 0.68-1.44）。同时发现，高钙摄入比低钙摄入的女性患乳腺癌的风险低19%（RR = 0.81，95% CI = 0.72-0.90）。该研究成果表明维生素D和钙在乳腺癌预防中的重要作用，提示女性日常生活中要注意通过营养膳食、多晒太阳等多渠道补充足够的维生素D和钙，以降低乳腺癌发生的风险。
本课题得到了中科院百人计划、营养所所长基金、国家自然科学基金委等资助。（生物谷Bioon.com）
生物谷推荐原始出处：
Breast Cancer Research and Treatment DOI:10.1007/s10549-009-0593-9
Meta-analysis of vitamin D, calcium and the prevention of breast cancer
Peizhan Chen1, 2, Pingting Hu1, 2, Dong Xie1, 2, Ying Qin1, 2, Fudi Wang1, 2 and Hui Wang1, 2
(1) Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Rm 427, 41# Building, 320 Yueyang Road, 200031 Shanghai, People’s Republic of China
(2) Graduate School of the Chinese Academy of Sciences, 200031 Shanghai, People’s Republic of China
Abstract Vitamin D and calcium intake have been suggested to have protective effects against breast cancer; however, the data have been inconclusive. The present meta-analysis examined the overall effects of vitamin D intake, circulating 25(OH)D and 1α,25(OH)2D levels, and calcium intake on breast cancer risk. Data from 11 studies on vitamin D intake, 7 studies on circulating 25(OH)D levels, 3 studies of circulating 1α,25(OH)2D levels, and 15 studies on calcium intake and breast cancer risk were included in this analysis. From the meta-analysis, there was a significant inverse relationship between vitamin D intake and breast cancer risk, with an overall relative risk (RR) of high versus low vitamin D intake for breast cancer of 0.91 (95% CI = 0.85–0.97). The highest quantile of circulating 25(OH)D was found to be associated with a 45% (OR = 0.55, 95% CI = 0.38–0.80) decrease in breast cancer when compared with the lowest quantile. No significant association for the circulating 1α,25(OH)2D level and breast cancer was found (OR = 0.99, 95% CI = 0.68–1.44). For calcium, a 19% (RR = 0.81, 95% CI = 0.72–0.90) decrease in breast cancer risk was found for those with highest quantile of calcium intake compared to the lowest quantile. These results provide strong evidence that vitamin D and calcium have a chemopreventive effect against breast cancer.
