美国一项最新研究成果显示，不育症男子患侵袭性前列腺癌的风险是有生育能力男子的2．6倍。研究人员建议，患不育症男子应特别重视前列腺检查。
这项研究是由美国华盛顿大学医学院完成的。研究成果刊登在3月刊《癌症》杂志上。
研究涉及2．2万名患不育症男子及同等数量的有生育能力的男子。经过10年跟踪调查，研究人员发现，有生育能力的男子患前列腺癌的比例为0．4％，而不育男子患前列腺癌的比例为1．2％。考虑年龄因素后，不育男子患前列腺癌的风险比其他男子高160％。
据美国官方提供的数据，前列腺癌是继皮肤癌之后困扰美国男性的一种常见疾病，美国每年新增前列腺癌患者19．2万人，而死于这一疾病的达2．7万人。多数美国医疗机构建议，男性应从50岁开始经常进行前列腺检查。（生物谷Bioon.com）
生物谷推荐原文出处：
Cancer DOI: 10.1002/cncr.25075
Increased risk of high-grade prostate cancer among infertile men
Thomas J. Walsh, MD, MS 1 2 *, Michael Schembri, BS 3, Paul J. Turek, MD 4, June M. Chan, ScD 2 5, Peter R. Carroll, MD, MPH 2 6, James F. Smith, MD, MS 2, Michael L. Eisenberg, MD 2, Stephen K. Van Den Eeden, PhD 7, Mary S. Croughan, PhD 3 5
1Department of Urology, University of Washington, Seattle, Washington
2Department of Urology, University of California at San Francisco, San Francisco, California
3Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California at San Francisco, San Francisco, California
4The Turek Clinic, San Francisco, California
5Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California
6Department of Urology, University of California at San Francisco Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California
7Division of Research, Kaiser Permanente, Oakland, California
BACKGROUND:
It has been reported that fatherhood status may be a risk factor for prostate cancer. In the current study, the authors examined the subsequent occurrence of prostate cancer in a cohort of men evaluated for infertility to determine whether male infertility is a risk factor for prostate cancer.
METHODS:
A total of 22,562 men who were evaluated for infertility from 1967 to 1998 were indentified from 15 California infertility centers and linked to the California Cancer Registry. The incidence of prostate cancer was compared with the incidence in an age-matched and geography-matched sample of men from the general population. The risk of prostate cancer in men with and those without male factor infertility was modeled using a Cox proportional hazards regression model.
RESULTS:
A total of 168 cases of prostate cancer that developed after infertility were identified. Men evaluated for infertility but not necessarily with male factors were not found to have an increased risk of cancer compared with the general population (standardized incidence ratio [SIR], 0.9; 95% confidence interval [95% CI], 0.8-1.1). This risk was found to be highest for men with male factor infertility who developed high-grade prostate cancer (SIR, 2.0; 95% CI, 1.2-3.0). On multivariate analyses, men with male factor infertility were found to be 2.6 times more likely to be diagnosed with high-grade prostate cancer (hazard ratio, 2.6; 95% CI, 1.4-4.8).
CONCLUSIONS:
Men with male factor infertility were found to have an increased risk of subsequently developing high-grade prostate cancer. Male infertility may be an early and identifiable risk factor for the development of clinically significant prostate cancer
