日本研究人员在新一期美国《国家科学院学报》网络版上报告说，通过阻止骨髓细胞内的某种蛋白质与激素结合，可防止大肠癌向肝脏转移。
京都大学遗传药理学教授武藤诚率领的研究小组在之前的研究中发现，部分含有蛋白质“CCR1”的骨髓细胞会被大肠癌细胞分泌的激素吸引并与其结合在一起，然后释放出酶。这种酶使正常的组织变得脆弱，这样癌细胞就容易转移和浸润到肝脏组织内部。
在本次实验中，研究人员让患有大肠癌的实验鼠摄入妨碍“CCR1”蛋白质与激素结合的物质，结果癌细胞的转移受到了抑制。与没有摄入上述物质的患病实验鼠相比，它们的平均生存期间延长了约1倍，达到62天。研究人员还利用注入了人类大肠癌细胞的实验鼠进行相同的实验，确认了上述方法可产生同样的抑制效果。
武藤诚指出：“这一发现有可能为预防大肠癌转移和开发治疗方法作出贡献。”(生物谷Bioon.net)
更多阅读
人CC趋化因子受体1(CCR1)ELISA Kit报价/价格
信号转导研究专题
生物谷推荐原文出处：
PNAS doi: 10.1073/pnas.1002372107
Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model
Takanori Kitamuraa,1, Teruaki Fujishitaa,1, Pius Loetscherb, Laszlo Reveszb, Hiroki Hashidac, Shinae Kizaka-Kondohd, Masahiro Aokia, and Makoto M. Taketoa,2
aDepartment of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan;
bNovartis Institutes for BioMedical Research, Novartis Pharma AG, CH-4056 Basel, Switzerland;
cDepartment of Gastroenterological Surgery and Oncology, Kitano Hospital, Osaka 530-8480, Japan; and
dDepartment of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan
Recent reports have suggested critical roles of myeloid cells in tumor invasion and metastasis, although these findings have not led to therapeutics. Using a mouse model for liver dissemination, we show that mouse and human colon cancer cells secrete CC-chemokine ligands CCL9 and CCL15, respectively, and recruit CD34+ Gr-1? immature myeloid cells (iMCs). They express CCL9/15 receptor CCR1 and produce matrix metalloproteinases MMP2 and MMP9. Lack of the Ccr1, Mmp2, or Mmp9 gene in the host dramatically suppresses outgrowths of disseminated tumors in the liver. Importantly, CCR1 antagonist BL5923 blocks the iMC accumulation and metastatic colonization and significantly prolongs the survival of tumor-bearing mice. These results suggest that CCR1 antagonists can provide antimetastatic therapies for patients with disseminated colon cancer in the liver.
