美国8日公布的一项最新研究显示，睡眠不足会提高患结肠腺瘤甚至结肠癌的风险。据称，这是研究人员首次发现睡眠不足与结肠腺瘤存在关联。
这项研究是由美国凯斯西储大学医学院等机构的研究人员完成的。研究涉及1240名病人，其中338人被诊断患有结肠腺瘤，而在这些患者中，大多数表示他们每天的睡眠时间不足6小时。
调查通过问询方式进行，所涉及的问题包括被调查对象在过去1个月的睡眠情况、是否经常有睡眠问题、每晚睡眠多长时间等。结果发现，每天平均睡眠不足6小时的人要比每天睡眠7小时以上的人更容易患结肠腺瘤，前者患此病的几率比后者高50％。结肠腺瘤有些是良性肿瘤，但有些也会转为恶性肿瘤。
相关研究成果刊登在新一期美国《癌症》杂志上。（生物谷Bioon.com）
生物谷推荐原文出处：
Cancer, 2011; 117 (4): 841 DOI: 10.1002/cncr.25507
Short duration of sleep increases risk of colorectal adenoma
Cheryl L. Thompson PhD1,2,3,4, Emma K. Larkin PhD2,3,5, Sanjay Patel MD3,4,5,6, Nathan A. Berger MD3,4,6, Susan Redline MD2,3,4,5, Li Li MD, PhD1,2,3,4,*
Keywords:sleep duration;quality of sleep;colorectal adenoma;Pittsburgh Sleep Quality Index
Abstract
BACKGROUND:
Short duration and poor quality of sleep have been associated with increased risks of obesity, cardiovascular disease, diabetes mellitus, and total mortality. However, few studies have investigated their associations with risk of colorectal neoplasia.
METHODS:
In a screening colonoscopy-based case-control study, the Pittsburg Sleep Quality Index (PSQI) was administered to 1240 study participants before colonoscopy.
RESULTS:
Three hundred thirty-eight (27.3%) of the participants were diagnosed with incident colorectal adenomas. Although there was no appreciable difference in the overall PSQI score between cases and adenoma-free controls (5.32 vs 5.11; P = .37), the authors found a statistically significant association of colorectal adenoma with the PSQI component 3, which corresponds to sleep duration (P = .02). Cases were more likely to average less than 6 hours of sleep per night (28.9% vs 22.1% in controls, P = .01). In multivariate regression analysis adjusted for age, gender, race, smoking, family history of colorectal cancer, and waist-to-hip ratio, individuals averaging less than 6 hours per night had an almost 50% increase in risk of colorectal adenomas (OR = 1.47; CI = 1.05-2.06, P for trend = .02) as compared with individuals sleeping at least 7 hours per night. Cases were also more likely to report being diagnosed with sleep apnea (9.8% vs 6.5%, P = .05) and more likely to have worked alternate shifts (54.0% vs 46.1%, P = .01), although these differences were not significant in multivariate models.
CONCLUSIONS:
Shorter duration of sleep significantly increases risk of colorectal adenomas. The authors' results suggest sleep duration as a novel risk factor for colorectal neoplasia.
