过去有研究显示,肥胖女性更容易罹患与雌激素过多有关的乳腺癌。美国一项最新研究则进一步发现,过度肥胖的绝经女性罹患三阴乳腺癌风险也相对较高。
上述结果是美国西雅图弗雷德·哈钦森癌症研究中心分析了逾15.5万名绝经女性的健康数据后发现的。这些研究对象的年龄在50岁至79岁之间,其中2610人患有与雌激素过多有关的乳腺癌,307名患有三阴乳腺癌。研究人员经对比其身体质量指数后发现,与体重正常人群相比,肥胖女性患三阴乳腺癌的风险高35%,患其他类型乳腺癌的风险高39%。
研究项目负责人阿曼达·菲普斯说,多数绝经女性的雌激素来自脂肪组织,人越胖,雌激素越多,所以过度肥胖的绝经女性患某些乳腺癌的几率相对较大。但与其他一些乳腺癌不同,三阴乳腺癌不受雌激素影响,所以过去有关这类癌症的研究忽视了身体肥胖因素。
这项研究成果已发表在最新一期美国《癌症流行病学、生物标志与预防》杂志上。(生物谷Bioon.com)
生物谷推荐原文出处:
Cancer Epidemiology, Biomarkers & Prevention doi: 10.1158/1055-9965.EPI-10-0974
Body Size, Physical Activity, and Risk of Triple-Negative and Estrogen Receptor–Positive Breast Cancer
Amanda I. Phipps1, Rowan T. Chlebowski2, Ross Prentice1, Anne McTiernan1, Marcia L. Stefanick3, Jean Wactawski-Wende4, Lewis H. Kuller5, Lucile L. Adams-Campbell6, Dorothy Lane7, Mara Vitolins8, Geoffrey C. Kabat9, Thomas E. Rohan9 and Christopher I. Li1
Abstract
Background: Triple-negative breast cancer, characterized by a lack of hormone receptor and HER2 expression, is associated with a particularly poor prognosis. Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk.
Methods: Using data from 155,723 women enrolled in the Women's Health Initiative (median follow-up, 7.9 years), we assessed associations between baseline body mass index (BMI), BMI in earlier adulthood, waist and hip circumference, waist–hip ratio, recreational physical activity, and risk of triple-negative (n = 307) and estrogen receptor–positive (ER+, n = 2,610) breast cancers.
Results: Women in the highest versus lowest BMI quartile had 1.35-fold (95% CI, 0.92–1.99) and 1.39-fold (95% CI, 1.22–1.58) increased risks of triple-negative and ER+ breast cancers, respectively. Waist and hip circumferences were positively associated with risk of ER+ breast cancer (Ptrend = 0.01 for both measures) but were not associated with triple-negative breast cancer. Compared with women who reported no recreational physical activity, women in the highest activity tertile had similarly lower risks of triple-negative and ER+ breast cancers (HR = 0.77; 95% CI, 0.51–1.13; and HR = 0.85; 95% CI, 0.74–0.98, respectively).
Conclusions: Despite biological and clinical differences, triple-negative and ER+ breast cancers are similarly associated with BMI and recreational physical activity in postmenopausal women. The biological mechanisms underlying these similarities are uncertain and these modest associations require further investigation.