据一项新的研究显示，规律摄入阿司匹林可使罹患皮肤癌风险降低40%。
哈佛大学医学院的科学家们证实，每日服用止痛药，至少5年，可降低罹患黑色素瘤的风险。
“我们的数据至少支持这一假设——长期稳定地服用阿司匹林有效果，”每日邮报引述共同作者Robert Stern博士告诉MSNBC的话说。
研究人员分析和比较了1000人的医疗纪录，不料竟发现其中有400人被确诊黑色素瘤。黑色素瘤是最致命的皮肤癌类型。
另一方面，发现未患黑色素瘤的人均有服用如阿司匹林等非甾体抗炎药（NSAIDS）较长时间的用药史。
然而，来自加州大学旧金山分校的Maryam Asgari博士反驳该项研究说，她未发现任何关于支持NSAID对降低罹患皮肤癌风险有作用的证据。
这项研究发表在《Journal of Investigative Dermatology》上。（生物谷Bioon.com）
生物谷推荐原文出处：
Journal of Investigative Dermatology doi:10.1038/jid.2011.58
Long-Term Use of Nonsteroidal Anti-inflammatory Drugs Decreases the Risk of Cutaneous Melanoma: Results of a United States Case–Control Study
Clara Curiel-Lewandrowski, Tamar Nijsten, Maria L Gomez, Loes M Hollestein, Michael B Atkins and Robert S Stern
Experimental and observational studies continue to demonstrate conflicting results regarding the role of several commonly used drugs as melanoma chemopreventive agents. This case–control study was designed to assess the associations between cutaneous melanoma (CM) and exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) and statins in current users. A total of 400 CM and 600 eligible age- and gender-matched community-based controls were prospectively recruited and interviewed. We assessed participants’ demographic characteristics, CM risk factors, and current and previous use of medications. Multivariable conditional logistic regression models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for associations between NSAIDs and/or aspirin (ASA), statin exposure, and CM risk. Half of the subjects were men (mean age 60 years). After adjusting for confounders, use of any type of NSAIDs for more than 5 years significantly reduced the risk of melanoma development compared with the low-exposure group (adjusted OR=0.57; 95% CI=0.43–0.77). Subgroup analyses showed that the observed risk reduction was primarily driven by continuous ASA use (>5 years adjusted OR=0.51, 95% CI=0.35–0.75). No significant protective effect was observed with statin exposure (OR=0.97, 95% CI=0.73–1.29). Long-term use of NSAIDs, especially ASA, is associated with a significantly decreased risk of CM development. Clinical intervention studies are warranted to further investigate the potential role of ASA and other NSAIDs as chemopreventive agents for CM.
