在发达国家50岁以上的男性中，前列腺癌是被诊断出的最常见癌症类型。研究人员最近发现了与前列腺癌相关的基因变异，新成果发表在7月在线出版的《自然—遗传学》期刊上。与过去报告的易发性位点结合在一起，新发现有可能解释在前列腺癌的发生中占25%的家族性风险。
Rosalind Eeles和同事合作，报告了对4574位癌症患者和4164位对照人员的泛基因组相关性分析结果，以及这些研究结果在自30个国际研究小组的51311位受试者上的重复。他们鉴别出与前列腺癌易患性相关的7个新基因组区域。如今，已鉴别出的前列腺癌易患性基因组位点超过了40个。(生物谷 Bioon.com)
生物谷推荐原文出处：
Nature Genetics doi:10.1038/ng.882
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G Giles,Gianluca Severi, Johanna Schleutker, Maren Weischer, Daniele Campa, Elio Riboli, Tim Key, Henrik Gronberg, David J Hunter, Peter Kraft, Michael J Thun, Sue Ingles, Stephen Chanock,Demetrius Albanes, Richard B Hayes, David E Neal,Freddie C Hamdy, Jenny L Donovan, Paul Pharoah,Fredrick Schumacher, Brian E Henderson,Janet L Stanford, Elaine A Ostrander,et.
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10?8 to P = 2.7 × 10?24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.
