美国研究人员8月15日报告说，动物研究显示，人参提取物活性成分——人参炔三醇和类似化合物有助于缓解某些癌症疗法的副作用。
位于纽约的斯隆－凯特林癌症研究所的研究人员合成了类似于人参炔三醇的化合物，然后在患有乳腺癌或结肠癌的实验鼠身上展开实验，测试这种化合物抵消化疗或放疗副作用的能力。结果显示，在接受放疗前为实验鼠注射这种化合物，可以减少放疗引起的体重减少和血细胞损伤。
研究人员认为，人参炔三醇和类似化合物都能减少抗癌药紫杉醇所致的外周神经损伤和恶心引发的体重下降，并能减少抗癌药5-氟尿嘧啶对红细胞和白细胞的损伤，从而减少服药者感染和贫血的风险。
这项研究成果当天发表在美国新一期《国家科学院院刊》上。研究人员表示，人参炔三醇和类似化合物可以成为辅助癌症治疗的一种临床选项。不过，在进行临床测试前，需要对人参炔三醇类似化合物的化学结构进行优化。(生物谷 Bioon.com)
doi:10.1073/pnas.1111332108
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Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol
Chou, Ting-Chao; Dong, Huajin; Zhang, Xiuguo; Lei, Xiaoguang; Hartung, John; Zhang, Yandong; Lee, Jun Hee; Wilson, Rebecca M.; Danishefsky, Samuel J.
We describe herein the discovery of a series of panaxytriol (PXT)-derived polyacetylene small molecules with promising cytoprotectiveactivity. In mouse xenograft models, we have demonstrated the capacity of our synthetic analogs to mitigate a range of cancertherapeutic agent-induced toxicities, including body weight loss, lethality, neurotoxicity, and hematotoxicity. Our PXT analogshave also been found to reduce radiation-induced body weight loss and lethality in mouse models. Moreover, several PXT analogsappear to exhibit moderate in vivo antiinflammatory activity as well as in vitro immunoenhancing capabilities. These compoundsappear to derive their activity through induction of cancer preventive phase 2 enzymes. The studies described herein suggestthat coadministration of a PXT-derived agent with cancer chemotherapeutics or radiation therapy may serve to mitigate a rangeof therapy-associated toxicities.
