2012年1月4日，据《每日科学》报道，根据发表于《癌症预防研究》期刊（一种美国癌症研究协会期刊）上的一项研究结果， 接受抗雌激素补充剂的乳腺癌女性患者可能会减少患黑色素瘤的风险。
Christine Bouchardy，医学博士，日内瓦大学教授和日内瓦癌症登记处的负责人，和他的同事分析了7360名在1980年和2005年之间患乳腺癌妇女的数据。这些妇女中大约有一半人（54％）接受了抗雌激素治疗。
研究人员追踪这些患者一直到2008年，并在后续期间记录了34例黑色素瘤病例。与接受抗雌激素治疗的患者相比，未接受抗雌激素治疗的患者患黑色素瘤的风险高出60％。
据Bouchardy，对雌激素在乳腺癌中作用持续增加的关注使科学家们开始思考，在其他癌症中雌激素发挥着什么作用。 "这些数据强化了先前的假设，即雌激素在黑色素瘤的发生中发挥了作用，"她说。
Bouchardy说，这可能是由于雌激素与黑色素细胞水平及人体皮肤中黑色素产生的增加有关，这些与早期黑色素瘤相关。然而，她警告广泛的抗雌激素补充防止总人口中的黑色素瘤。
"这些结果需要在其他研究中进一步重复，特别是要考虑到这种药物众多的副作用，"Bouchardy说。
这项研究由一个非营利性组织--瑞士癌症研究基金会资助。（生物谷bioon.com）
doi:10.1158/1940-6207.CAPR-11-0332
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.Antiestrogen Therapy for Breast Cancer Modifies the Risk of Subsequent Cutaneous Melanoma.
C. Huber, C. Bouchardy, R. Schaffar, I. Neyroud-Caspar, G. Vlastos, F.-A. Le Gal, E. Rapiti, S. Benhamou.
Abstract： Increased risk of secondary melanoma after breast cancer has been reported. Several lines of evidence suggest that elevated estrogen levels may be implicated in melanoma etiology. Accordingly, use of antiestrogens should be associated with decreased risk of melanoma. We compared melanoma incidence among a cohort of breast cancer patients with and without antiestrogen therapy, with data from the Geneva Cancer Registry. The cohort consisted of 7,360 women diagnosed with breast cancer between 1980 and 2005. About 54% of these patients received antiestrogens. All women were followed until December 2008. We compared cutaneous melanoma incidence rates among patients with and without antiestrogens with those expected in the general population by age and period standardized incidence ratios (SIR). A total of 34 women developed a melanoma during the follow-up period. Compared with the general population, the risk of melanoma was higher for patients who did not receive antiestrogens (SIR: 1.60, 95% CI: 1.08–2.12,P = 0.02). On the contrary, the risk was close to 1 (SIR: 0.98, 95% CI: 0.40–1.56, P = 0.57) for patients who received antiestrogen therapy. This study suggests that antiestrogen therapy modifies the risk of melanoma after breast cancer. Although our results are in agreement with the hypothesis that estrogens could play a role in melanoma occurrence, they need to be replicated in a larger study with data on potential confounders. Cancer Prev Res; 5(1); 82–88. ©2011 AACR.
