2011年5月，《英国医学杂志》刊登欧洲多国进行的一项大规模研究显示，饮酒与癌症之间存在非常明显的关联，男性癌症病例中有十分之一都可以归结到与饮酒有关，研究人员因此呼吁人们为了身体健康应该减少饮酒量。
近日，Am J Clin Nutr杂志刊登的一项针对87000多名女性和47000多名男性的研究成果。该研究的主要工作者旨在找到大肠癌与酒精之间的联系，如果两者之间有联系，研究人员想进一步探讨酒精摄入量以及饮酒家族史与大肠癌的之间的相关性。在这项研究过程中，自1980年来，共有1801例大肠癌患者通过随访被确诊。
研究结果表明：有饮酒家族史的人每日摄入酒精量多于30克将大大增加罹患大肠癌的风险。罹患大肠癌最大风险的做法是吃红肉、大量吸烟、极少摄入叶酸等。而没有饮酒家族史的受试者则未显示出酒精摄入和罹患大肠癌之间的相关性。
但研究并没有对饮酒形式包括规律饮酒或偶尔大量饮酒进行相关评测，同时研究数据也不能表明罹患癌症的风险随饮酒量增加而提高。研究数据也证明：饮酒家族史阳性者在摄入足量的叶酸后，并不能降低罹患大肠癌的风险，相关人士认为诸如健康饮食等其他生活习惯可能在大肠癌发病因素中也起重要作用。
总之，这个研究再次支持了具有饮酒家族史的人大量饮酒会增加患癌几率这一观点。(生物谷 Bioon.com)
doi:10.3945/ajcn.111.022145
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Alcohol consumption and the risk of colon cancer by family history of colorectal cancer
Eunyoung Cho,Jung Eun Lee,Eric B Rimm,Charles S Fuchs, andEdward L Giovannucci
Background: Individuals with a family history of colorectal cancer may be more susceptible to adverse effects of alcohol consumption.
Objective: We investigated whether the association between alcohol consumption and colon cancer risk differed by family history of colorectal cancer.
Design: We conducted prospective studies in women and men in the Nurses’ Health Study and Health Professionals Follow-Up Study, respectively. Alcohol consumption was first assessed in 1980 in women and in 1986 in men.
Results: During a follow-up of 26 y among 87,861 women and 20 y among 47,290 men, we documented 1801 cases of colon cancer (1094 women and 707 men). Higher alcohol consumption was associated with an elevated risk of colon cancer, although the association was significant only for the highest intake category of ≥30 g/d, with no significant linear trend. The association between alcohol consumption and colon cancer risk differed by family history of colorectal cancer; in comparison with nondrinkers, the pooled multivariate RRs for alcohol consumption of ≥30 g/d were 1.23 (95% CI: 0.96, 1.57; NS) among those with no family history and 2.02 (95% CI: 1.30, 3.13) among those with a family history of colorectal cancer (P value test for difference = 0.05). In comparison with nondrinkers with no family history, the RR for colon cancer was 2.80 (95% CI: 2.00, 3.91) for individuals who consumed ≥30 g/d and who had a family history of colorectal cancer.
Conclusion: Reducing alcohol consumption may decrease the incidence of colon cancer, especially among those with a family history of colorectal cancer.
