4月3日，发表在Lung Cancer上的一项新研究调查了超过1200名亚洲妇女，发现每周服用几次阿司匹林，患肺癌的风险要低得多——不管她们是否吸烟。该研究认为阿司匹林可降低风险50%以上，但不能证明阿司匹林有直接对抗肺癌的作用。但是他们支持其他研究显示的常规阿司匹林使用和特定癌症风险降低的关联，包括结肠癌、前列腺癌和食管癌。
尽管如此，专家们说推荐广泛服用阿司匹林降低癌症风险还为时尚早。阿司匹林是否对抗肺癌的问题仍然需要讨论，目前公布的证据还不能定论。
这项研究纳入了398名诊断为肺癌的中国女性，和814名没有癌症的妇女。研究发现那些定期服用阿司匹林的女性（一周至少2次，持续1月以上），肺癌风险降低。
研究人员调整了其他因素，包括年龄、教育程度和水果蔬菜摄入量。但应该仍存在其他因素可以帮助解释阿司匹林为什么可以降低肺癌风险。
阿司匹林使用者和非使用者之间癌症风险的相对差异较大，但是对于个人绝对风险的降低可能比较小。
Andrew T. Chan博士没有参与这项研究，他讲到，阿司匹林和肺癌之间关联的证据比较混杂，阿司匹林可预防结肠癌的证据较强。我不认为本研究的证据比较明确，推荐所有中年人和老年人每日服用阿司匹林还尚早。
但是医生和患者讨论低剂量阿司匹林的利弊是很合理的，人们通常对预防多种肿瘤更感兴趣，但是也需要了解阿司匹林的风险。（生物谷Bioon.com）
doi:10.1016/j.lungcan.2012.03.005
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Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer
Wei-Yen Lima, , , Khoon Leong Chuahb, Philip Engc, Swan Swan Leongd, Elaine Limb, Tow Keang Lime, Alan Ngb, Wee Teng Pohf, Augustine Teef, Ming Tehe, Agus Salima, Adeline Seowa
There is evidence that aspirin and non-aspirin non-steroidal anti-inflammatory drug (NSAID) have anti-carcinogenic properties, but their effect on lung cancer, in particular in never-smokers, is unclear. Information on past or current use of anti-inflammatory medication was obtained in 398 Chinese female primary lung cancer cases and 814 controls in a hospital-based study in Singapore. 65% of cases and 88% of controls were never-smokers. Controls were excluded if they had been admitted for conditions associated with aspirin or NSAID use (n = 174). Regular aspirin use (twice a week or more, for a month or more) was associated with a reduced risk of lung cancer (adjusted odds ratio [OR] 0.50, 95% confidence intervals [95%CI] 0.31–0.81 in non-smokers; OR 0.38, 95%CI 0.16–0.93 in smokers). Regular use of non-aspirin NSAID, paracetamol, steroid creams and steroid pills was uncommon and no association with lung cancer was detected. Our results suggest that aspirin consumption may reduce lung cancer risk in Asian women and are consistent with current understanding of the role of cyclooxygenase in lung carcinogenesis.
