生物谷报道：生命体系中诸多基本结构单元在特定的环境下，能自发地进行自组装，形成各种各样的纳米结构。肽基的自组装体系可以作为组织修复的骨架，用于生物工程界面和跨膜离子通道的研究，其在药物、蛋白和基因的传输方面有很好的应用前景。
在中国科学院和国家自然科学基金委的支持下，胶体、界面与化学热力学院重点实验室的研究人员在仿生体系的分子组装方面取得新进展，相关研究工作发表在近期的Angew. Chem. Int. Ed. (2007, 46, 2431-2434)上。
前期工作中，该研究组利用“微乳法”和“层层组装技术”在仿生膜的分子组装方面取得系列进展(Angew. Chem. Int. Ed. 2001, 40 , 891；ChemBioChem., 2003, 4, 299； ChemPhysChem, 2003, 4, 1355；J. Phys. Chem. B, 2004, 108, 473)。用分子组装的方法和概念，在流体表面或生物基质中，进行仿生物膜结构的有序组装，通过对组装膜的结构与功能进行调控，使组装体系在某种程度上具有生物膜的功能。
在以上工作基础上，研究人员发现阳离子二肽在中性条件下可以自组装成纳米管，通过改变自组装体系的浓度，纳米管能进一步转化为囊泡，利用此转变过程可将寡核苷酸(ss-DNA)通过细胞的吞噬作用携入细胞内，从而实现外缘物质的胞内输送。该研究工作为肽基生物材料在药物传输方面的应用提供了实验基础。（引自化学研究所）
原始出处:
Angewandte Chemie International Edition , Volume 46, Issue 14 , Pages 2431 - 2434
Published Online: 28 Feb 2007
Transition of Cationic Dipeptide Nanotubes into Vesicles and Oligonucleotide Delivery
Xuehai Yan 1, Qiang He, Dr. 1 2, Kewei Wang 1, Li Duan 1, Yue Cui, Dr. 1, Junbai Li, Prof. Dr. 1 *
1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
2Max Planck Institute of Colloids and Interfaces, 14476 Golm/Potsdam, Germany
email: Junbai Li (jbli@iccas.ac.cn)
*Correspondence to Junbai Li, 1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
Communication
Transition of Cationic Dipeptide Nanotubes into Vesicles and Oligonucleotide Delivery
Xuehai Yan 1, Qiang He, Dr. 1 2, Kewei Wang 1, Li Duan 1, Yue Cui, Dr. 1, Junbai Li, Prof. Dr. 1 *
1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
2Max Planck Institute of Colloids and Interfaces, 14476 Golm/Potsdam, Germany
email: Junbai Li (jbli@iccas.ac.cn)
*Correspondence to Junbai Li, 1Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Laboratory, Key Laboratory of Colloid and Interface Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, P. R. China, Fax: (+86) 10-8261-2629
This work was supported financially by the National Natural Science Foundation of China (Nos. 20574077, 20471063, 20403022, and 90206035) and the Chinese Academy of Sciences, as well as the German Max Planck Society collaboration project. The authors acknowledge Hans Riegler for critical reading of the manuscript.
Funded by:
National Natural Science Foundation of China; Grant Number: 20574077, 20471063, 20403022, 90206035
Chinese Academy of Sciences
Max Planck Society
Keywords
cells ?oligonucleotides ?peptide nanotubes ?self-assembly ?vesicles
