美国宾夕法尼亚大学的研究人员10月4日报告说，他们以小鼠为模型进行的动物研究显示，绿茶中的一种名为EGCG的儿茶素可以抑制小鼠体重增加，该物质有望成为对抗肥胖的新制剂。
研究人员在美国《肥胖》杂志网络版上介绍说，他们给两组小鼠喂食同样数量的高脂食物，其中一组同时喂食EGCG儿茶素。研究人员发现，EGCG组小鼠增加的体重比另一组低45%，前者排泄物中的脂质比另一组高出约30%，这意味着EGCG儿茶素抑制了小鼠对脂肪的吸收。
领导这项研究的宾夕法尼亚大学助理教授乔舒亚-兰伯特说，EGCG儿茶素似乎既能增强小鼠对脂肪的利用，同时也降低小鼠对脂肪的吸收。
兰伯特指出，一个人可能每天需要喝10杯绿茶才能吸取与上述小鼠摄入量相当的EGCG儿茶素，不过近来有其他研究显示，每天喝几杯绿茶就有助于控制体重。
“尽管目前与喝绿茶有关的体重数据不是很多，但仍可表明，与不喝绿茶相比，每天只需饮用一杯以上的绿茶就能看到对体重带来的影响，”兰伯特说。（生物谷 Bioon.com）
doi:10.1038/oby.2011.139
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(|[minus]|)-Epigallocatechin-3-gallate Inhibits Pancreatic Lipase and Reduces Body Weight Gain in High Fat-Fed Obese Mice
Kimberly A. Grove, Sudathip Sae-tan, Mary J. Kennett, Joshua D. Lambert
Tea (Camellia sinensis, Theaceae) has been shown to have obesity preventive effects in laboratory studies. We hypothesized that dietary epigallocatechin-3-gallate (EGCG) could reverse metabolic syndrome in high fat-fed obese C57bl/6J mice, and that these effects were related to inhibition of pancreatic lipase (PL). Following treatment with 0.32% EGCG for 6 weeks, a 44% decrease in body weight (BW) gain in high fat-fed, obese mice (P < 0.01) was observed compared to controls. EGCG treatment increased fecal lipid content by 29.4% (P < 0.05) compared to high fat-fed control, whereas in vitro, EGCG dose-dependently inhibited PL (IC50 = 7.5 µmol/l) in a noncompetitive manner with respect to substrate concentration. (−)-Epicatechin-3-gallate exhibited similar inhibitory activity, whereas the nonester-containing (−)-epigallocatechin did not. In conclusion, EGCG supplementation reduced final BW and BW gain in obese mice, and some of these effects may be due to inhibition of PL by EGCG.
