《核酸研究》（Nucleic Acids Research）杂志于11月9日在线发表了中国科学院上海生命科学研究院生物化学与细胞生物学研究所季红斌研究组与华东师范大学石铁流研究组合作开发的一个肺癌相关基因、蛋白以及小分子RNA的信息库平台。
肺癌是危害人类的重大疾病之一，具有非常高的致死率，在全球范围内其五年生存率大约为15%，而在我国还不足10%。近几十年以来集中于肺癌的基础研究或转化应用研究已经积累了一系列的数据和信息，但起劲还没有一个平台可以给科研工作者提供系统性的信息服务。
季红斌研究组与石铁流研究组合作，分析了271个肺癌样本的表达谱数据，同时结合文献数据的人工挖掘，建立了一个整合肺癌相关基因、蛋白（主要是转录因子）以及小分子RNA的信息平台。该平台目前包括在肺癌发生发展不同阶段起作用的2585个基因和212个小分子RNA，并整合其启动子区域分析、表观遗传学改变和SNP位点分析。此外，该平台还包括在肺癌发病过程中一些重要的信号通路。用户可以直接通过平台链接浏览与肺癌相关的基因、小分子RNA、SNP位点、甲基化以及信号通路等等。这一肺癌相关信息平台的建立不仅有助于对某些特定的分子或生物学标记物进行深入的了解，而且为系统性地研究肺癌发病相关的分子机理奠定了坚实的基础。
该项研究工作得到了国家科技部、基金委、中国科学院和上海市科委的经费支持。（生物谷Bioon.com）
生物谷推荐原始出处：
Nucleic Acids Research, doi:10.1093/nar/gkp945
HLungDB: an integrated database of human lung cancer research
Lishan Wang1, Yuanyuan Xiong1, Yihua Sun2, Zhaoyuan Fang2, Li Li2, Hongbin Ji2,* and Tieliu Shi1,3,*
1Center for Bioinformatics and Computational Biology, and The Institute of Biomedical Sciences, College of Life Science, East China Normal University, Shanghai 200241, 2Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology and 3Shanghai Information Center for Life Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China
The human lung cancer database (HLungDB) is a database with the integration of the lung cancer-related genes, proteins and miRNAs together with the corresponding clinical information. The main purpose of this platform is to establish a network of lung cancer-related molecules and to facilitate the mechanistic study of lung carcinogenesis. The entries describing the relationships between molecules and human lung cancer in the current release were extracted manually from literatures. Currently, we have collected 2585 genes and 212 miRNA with the experimental evidences involved in the different stages of lung carcinogenesis through text mining. Furthermore, we have incorporated the results from analysis of transcription factor-binding motifs, the promoters and the SNP sites for each gene. Since epigenetic alterations also play an important role in lung carcinogenesis, genes with epigenetic regulation were also included. We hope HLungDB will enrich our knowledge about lung cancer biology and eventually lead to the development of novel therapeutic strategies. HLungDB can be freely accessed at http://www.megabionet.org/bio/hlung.
