生物谷报道：骨质疏松症（Osteoporosis）是一种最常见的骨头代谢性的疾病，它会造成持续性的骨密度减少，造成骨头脆弱；但是同时骨头的矿物质和有机质的组成比例仍然维持不变。由于骨密度较低，骨头强度较弱，所以容易造成骨折。在美国，每年大约有2000万人受到骨质疏松症的影响，其中有130万人造成骨折。
在正常的骨头中，骨头的形成与再吸收大致上达成一个动态的平衡；但是在骨质疏松症的病人，再吸收的速度大于形成的速度，造成骨头质量的减少。
虽然女性发生骨质疏松症的比率比男性高出四倍，但是每12名男性中，还是有一人会发生骨质疏松症。
骨质疏松症的潜在原因很多，一般认为女性的骨质疏松症主要是由于更年期过后雌性激素含量减少所致。
根据一篇由华盛顿大学医学院发表的新研究指出，男性体内的雌性激素含量过低也会增加他们发生骨质疏松症的风险。
睪固酮使男性骨头更大且更厚实，但雌性激素却是为持骨头矿物质含量的关键激素。研究人员也观察了其它因素与骨质密度间的关连性，包括抽烟、饮酒量、每日钙摄取量和身体质量指数(BMI)。结果只发现BMI与骨头密度有关，BMI较高的男性有较高的骨头密度。
(资料来源 : Bio.com)
英文原文链接：
原始出处:
Calcified Tissue International，Volume 80, Number 4 / 2007年4月
10.1007/s00223-007-9014-4
Estrogen Metabolism Modulates Bone Density in Men
N. Napoli1, 3 , R. Faccio2, V. Shrestha3, S. Bucchieri4, G. Battista Rini4 and R. Armamento-Villareal1
(1) Division of Bone and Mineral Diseases, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
(2) Department of Orthopedics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
(3) Department of Medicine, University of Palermo, Via del Vespro 141, 90127, Palermo, Italy
(4) Department of Medicine, St. Luke’s Hospital, Chesterfield, MO, USA
Received: 26 June 2006 Accepted: 9 January 2007 Published online: 4 April 2007
Abstract
Abstract Estrogen is a critical hormone for bone homeostasis in men, but no information is available on the role of estrogen metabolism among men. The aim of this study was to evaluate the effect of estrogen hydroxylation on male bone mineral density (BMD). Participants consisted of 61 healthy Caucasian males (mean age 66.6 ± 1.0 years). Urinary estrogen metabolites were measured by enzyme-linked immunosorbent assay, serum estradiol by ultrasensitive radioimmunoassay, sex hormone binding globulin by radioimmunoassay, and BMD of the lumbar spine and the proximal femur by dual-energy X-ray absorptiometry. Active estrogen metabolites, 16α-hydroxyestrone (16αOHE1) and estriol (E3), positively correlated with adjusted BMD in all regions of the proximal femur (all P < 0.05) but not at the lumbar spine, and those in the highest tertile of urinary 16αOHE1 had the highest BMD. Free estradiol index (FEI) also positively correlated with BMD of the total hip, femoral neck, and intertrochanter (all P < 0.05), while there was no correlation between BMD with inactive metabolites (2−hydroxyestrone and 2-methoxyestrone) and serum testosterone. Multiple regression analysis showed 16αOHE1, FEI, and body mass index are important independent predictors of BMD in all regions of the proximal femur. Estrogen metabolism may modulate BMD in men. Increased urinary 16αOHE1 and E3 levels are associated with high BMD at the proximal femur, and 16αOHE1 appears to be a major determinant of BMD among the metabolites evaluated.
Keywords Male osteoporosis - Estrogen metabolism - Bone mineral density
