生物谷报道：美国辛辛那提大学的研究人员发现，用患者自身的血小板制成的一种浓缩凝聚来治疗皮肤伤口能够加快伤口的愈合。这项研究结果发表在Archives of Facial Plastic Surgery杂志上。
这项研究的领导者、耳鼻喉科专家David Hom博士与面部整形医生一同完成了这项研究。研究组发现，与对照的抗生素药膏相比，使用患者自身的血小板凝胶治疗皮肤创伤的恢复速更快。
研究人员对21－58岁的8名志愿者（4男4女）进行了研究：先在志愿者两条大腿上制造皮肤创伤（直径4mm），然后用血小板凝胶治疗一条腿上的创伤，而另一条腿上的创伤则用抗生素药膏处理。在接下来的六个月里，研究人员对伤口愈合状况进行跟踪调查。
跟踪结果显示，在一个为期42天的周期里，研究人员发现用血小板凝胶处理的皮肤创伤比抗生素处理的皮肤创伤明显愈合较快。
分析显示，生长因子在伤口愈合中发挥重要作用，对用血小板凝胶处理的伤口部位，其促进愈合的生长因子含量也明显增加了。
原始出处:
Arch Facial Plast Surg. 2007;9:174-183.
The Healing Effects of Autologous Platelet Gel on Acute Human Skin Wounds
David B. Hom, MD; Bradley M. Linzie, MD; Trevor C. Huang, PhD
Objective To compare the healing of full-thickness skin punch wounds treated with topical autologous platelet gel (APG) vs conventional therapy (antibiotic ointment and/or occlusive dressings) in healthy volunteers.
Methods A prospective, single-blind, pilot study comprising 80 full-thickness skin punch wounds (4 mm diameter) was conducted on the thighs of 8 healthy volunteers. With each subject serving as his or her own control (5 punch sites per leg), APG was applied topically on one thigh, and an antibiotic ointment and/or a semiocclusive dressing was applied on the other thigh. Healing was monitored for spontaneous wound closure by clinical assessment and by digital photographs over 6 months. Over 35 days, 64 serial dermal biopsy specimens (6 mm diameter) were analyzed (using hematoxylin-eosin, Mason trichrome, CD-34, and Ki-67 stains) to measure differences between treated and control sites for cellularity, granulation formation, vascularity, epithelialization, and cellular replication.
Results Over a 42-day period, the APG-treated sites had statistically increased wound closure compared with controls by visual clinical assessment and by digital planimetry photographic measurements (P.02). On day 17, the percentage of closure was 81.1% ± 2.5% (mean ± SE) for the APG-treated sites and 57.2% ± 5.9% for the control sites. Also, the APG wound closure velocities were significantly faster than those of the controls (P = .001). Histologically, over time, the APG-treated sites had similar cellularity, cellular replication, granulation tissue, vascularity, and epithelialization compared with controls. However, when the platelet count in the gel was more than 6 times the baseline intravascular platelet count in some subjects, epithelialization and granulation formation appeared 3 days earlier in the APG-treated group. Furthermore, in vitro testing of supplemental APG showed increased endothelial cell proliferation compared with controls (P<.04).
Conclusion This pilot study provides preliminary evidence that topical APG may hasten wound closure in full-thickness dermal wounds in healthy individuals.
Trial Registration clinicaltrials.gov Identifier: NCT00199992
Author Affiliations: Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Minnesota School of Medicine and Hennepin County Medical Center (Dr Hom), Department of Pathology, Hennepin County Medical Center (Dr Linzie), and Medtronic Inc (Dr Huang), Minneapolis, Minn. Dr Hom is now with the Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology–Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.
