生物谷报道：美国研究人员的研究结果显示，维生素D含量低的人群罹患心脏病、心力衰竭及中风的风险较高。
据美国《循环》（Circulation）月刊最近公布的一项研究结果，研究人员耗时5年跟踪调查了1739名平均年龄为59岁的研究对象，他们均没有心血管病史。研究人员定期给他们采血，测维生素D含量。
研究结果显示，即使将糖尿病、高胆固醇和高血压等这些易导致心血管疾病的因素全部考虑进去，与维生素D含量高的人群相比，含量低的人群患心脏病、心力衰竭和中风的风险要高60%，如果还同时患有高血压的话，这种风险将加倍。
研究人员说，这一发现令人振奋，但现在就说摄入维生素D便可以降低心脏病等风险还为时尚早，暂时也无法建议人们出于此目的而摄取维生素D。
专家建议，为改善缺乏维生素D的症状，人们可采用常晒太阳、食用牛奶和多脂肪鱼类等手段。一周晒3次太阳，每次10到15分钟，就能获取所需要的维生素D量。
另据英国科学家的研究结果，维生素D吸收较多的人，衰老速度较缓慢。人体90%的维生素D通过日照获得，因此维生素D又被称为“阳光维生素”。较常接受日照的人比避免日照的人生理机能年轻5岁。（来源：新华网）
（《循环》（Circulation），doi: 10.1161/CIRCULATIONAHA.107.706127，Thomas J. Wang, Ramachandran S. Vasan）
生物谷推荐原始出处：
Circulation
Published Online
on January 7, 2008
Submitted on April 4, 2007
Accepted on November 2, 2007
Vitamin D Deficiency and Risk of Cardiovascular Disease
Thomas J. Wang MD*, Michael J. Pencina PhD, Sarah L. Booth PhD, Paul F. Jacques DSc, Erik Ingelsson MD, PhD, Katherine Lanier BS, Emelia J. Benjamin MD, MSc, Ralph B. D’Agostino PhD, Myles Wolf MD, MMSc, and Ramachandran S. Vasan MD
From the Framingham Heart Study, Framingham, Mass (T.J.W., M.J.P., E.I., K.L., E.J.B., R.B.D., R.S.V.); Cardiology Division (T.J.W.) and Renal Division (M.W.), Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Statistics and Consulting Unit, Department of Mathematics (M.J.P., R.B.D.), Boston University, Boston, Mass; Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging (S.L.B., P.F.J.), Tufts University, Boston, Mass; and Sections of Cardiology and Preventive Medicine (E.J.B., R.S.V.), Boston Medical Center, Boston University School of Medicine, Boston, Mass.
* To whom correspondence should be addressed. E-mail: tjwang@partners.org .
Background—Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking.
Methods and Results—We studied 1739 Framingham Offspring Study participants (mean age 59 years; 55% women; all white) without prior cardiovascular disease. Vitamin D status was assessed by measuring 25-dihydroxyvitamin D (25-OH D) levels. Prespecified thresholds were used to characterize varying degrees of 25-OH D deficiency (<15 ng/mL, <10 ng/mL). Multivariable Cox regression models were adjusted for conventional risk factors. Overall, 28% of individuals had levels <15 ng/mL, and 9% had levels <10 ng/mL. During a mean follow-up of 5.4 years, 120 individuals developed a first cardiovascular event. Individuals with 25-OH D <15 ng/mL had a multivariable-adjusted hazard ratio of 1.62 (95% confidence interval 1.11 to 2.36, P=0.01) for incident cardiovascular events compared with those with 25-OH D 15 ng/mL. This effect was evident in participants with hypertension (hazard ratio 2.13, 95% confidence interval 1.30 to 3.48) but not in those without hypertension (hazard ratio 1.04, 95% confidence interval 0.55 to 1.96). There was a graded increase in cardiovascular risk across categories of 25-OH D, with multivariable-adjusted hazard ratios of 1.53 (95% confidence interval 1.00 to 2.36) for levels 10 to <15 ng/mL and 1.80 (95% confidence interval 1.05 to 3.08) for levels <10 ng/mL (P for linear trend=0.01). Further adjustment for C-reactive protein, physical activity, or vitamin use did not affect the findings.
Conclusions—Vitamin D deficiency is associated with incident cardiovascular disease. Further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.
Key words: cardiovascular diseases • risk factors • vitamin D
