基因调控网络(GRN)这个概念在关于动物身体平面的形成过程的研究中的应用,是系统生物学何以能够为活生物的基因组调控序列是如何工作的提供因果关系解释的一个例子。在本期Nature的一篇Review文章中,Eric Davidson描绘了GRN的一个画面,这个画面所依据的是对数量虽少、但却不断增长的、目前已确认的GRN所进行的研究工作,同时他还强调了分子生物功能与基因组之间的联系。(生物谷Bioon.com)
生物谷推荐原文出处:
Nature doi:10.1038/nature09645
Emerging properties of animal gene regulatory networks
Gene regulatory networks (GRNs) provide system level explanations of developmental and physiological functions in the terms of the genomic regulatory code. Depending on their developmental functions, GRNs differ in their degree of hierarchy, and also in the types of modular sub-circuit of which they are composed, although there is a commonly employed sub-circuit repertoire.