减数分裂过程中配对的同源染色体是如何相互识别在植物的研究工作相对发表文章较少。虽然功能上是保守的，但不同物种的同源染色体配对起始及机制可能不同。
韩方普实验室长期从事植物减数分裂及着丝粒的表观遗传学研究，该研究组以玉米减数分裂突变体及含有双着丝粒染色体的植株为材料，发现着丝粒配对先于端粒的bouquet并在同源染色体配对其重要作用。同源染色体配对起重要作用的是着丝粒的活性而不是着丝粒的特异序列。
该研究结果于2013年10月18日在线发表于Plant Cell杂志上(doi:10.1105/tpc.113.117846 )。韩方普实验室博士生张晶为该论文的第一作者。相关研究得到科技部的资助。(生物谷Bioon.com)
生物谷推荐的英文摘要
Plant Cell doi:10.1105/tpc.113.117846
Centromere Pairing in Early Meiotic Prophase Requires Active Centromeres and Precedes Installation of the Synaptonemal Complex in Maize
Jing Zhang, Wojciech P.Pawlowskic and Fangpu Han
Pairing of homologous chromosomes in meiosis is critical for their segregation to daughter cells. In most eukaryotes, clustering of telomeres precedes and facilitates chromosome pairing. In several species, centromeres also form pairwise associations, known as coupling, before the onset of pairing. We found that, in maize (Zea mays), centromere association begins at the leptotene stage and occurs earlier than the formation of the telomere bouquet. We established that centromere pairing requires centromere activity and the sole presence of centromeric repeats is not sufficient for pairing. In several species, homologs of the ZIP1 protein, which forms the central element of the synaptonemal complex in budding yeast (Saccharomyces cerevisiae), play essential roles in centromere coupling. However, we found that the maize ZIP1 homolog ZYP1 installs in the centromeric regions of chromosomes after centromeres form associations. Instead, we found that maize STRUCTURAL MAINTENANCE OF CHROMOSOMES6 homolog forms a central element of the synaptonemal complex, which is required for centromere associations. These data shed light on the poorly understood mechanism of centromere interactions and suggest that this mechanism may vary somewhat in different species.
