生物谷报道本周Science再发一篇有关Prion蛋白的报道,这是Prion研究中的新进展。有关它的报道在生物谷内有多篇。
Neuronal death is a prominent, but poorly understood, pathological hallmark of prion disease. Notably, in the absence of the cellular prion protein (PrPC), the disease-associated isoform, PrPSc, appears not to be intrinsically neurotoxic, suggesting that PrPC itself may participate directly in the prion neurodegenerative cascade. Here, cross-linking PrPC in vivo with specific monoclonal antibodies was found to trigger rapid and extensive apoptosis in hippocampal and cerebellar neurons. These findings suggest that PrPC functions in the control of neuronal survival and provides a model to explore whether cross-linking of PrPC by oligomeric PrPSc can promote neuronal loss during prion infection.
Original article:
Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo
Laura Solforosi, Jose R. Criado, Dorian B. McGavern, Sebastian Wirz, Manuel Sánchez-Alavez, Shuei Sugama, Lorraine A. DeGiorgio, Bruce T. Volpe, Erika Wiseman, Gil Abalos, Eliezer Masliah, Donald Gilden, Michael B. Oldstone, Bruno Conti, and R. Anthony Williamson
Science Mar 5 2004: 1514-1516. Published online January 29, 2004 [DOI: 10.1126/science.1094273] (in Science Express Reports ) [Abstract] [Full Text] [PDF] [Supporting Online Material]
Related article:
Prion蛋白是神经细胞凋亡的关键
Prion Pathway
