生物谷报道：阿尔茨海默病愈发危险，其致病原因到目前仍然不是很清楚。研究表明很多种金属可能参与AD的发生. 2006年11月发表的AD杂志的特别双刊上刊登了14篇关于金属在AD生化和物理中作用的精彩文章，它们是客串编辑的Andrei C. Miu 和 Oana Benga收集起来的。这些文章包含了六大类:综合性历史回顾的综述、方法学观点、当前研究综述、整合遗传和病理遗传报告、危险因素综述以及从实验台到临床的综述。
John Savory, Mary M. Herman 和 Othman Ghribi综述了一个争议了40年的铝神经细胞毒性的问题，重审那些关于铝细胞毒性下的可能细胞机制和针对铝细胞毒性潜在的神经细胞保护作用的数据。Paul A. Adlard 和Ashley I. Bush在接下来的综述里，讨论了象锌和铜等金属离子是如何通过参与正常细胞蛋白的聚集和参与产生活性氧而加重AD的。第三个综述里，Arezoo Campbell集中讨论了在衰老的脑中铝和铜是如何启动或者加重炎症反应。在最后的综述文章里，Andrei C. Miu 和Oana Benga重述曾经提出的铝在AD中作用的假说。
Bettina Platt讨论了那些一直被用来寻找AD及相关疾病中内毒素作用靶点的方法。关于方法的第二篇文章中，Joanna Collingwood 和 Jon Dobson写了有关最近用于发现和定位神经退化疾病组织中铁化合物的方法。
Robert A. Yokel综述了金属通过血脑屏障的运动。已经报道有许多转运体可以帮助金属转运进出脑。Robert A. Yokel综述了这些转运体在移动铝、镁、铁及其它金属穿过血脑屏障中的作用。
Hani Atamna创造出一种新的beta淀粉样蛋白诱导血红素缺陷的模型，这个模型模仿AD病人中的神经退化。他阐述了基因、营养和细胞毒素影响血红素代谢及和AD的相关性。James R. Connor 和Sang Y. Lee讨论了HFE基因突变可以影响脑中铁离子的平衡，从而潜在的导致产生活性氧和氧化损伤。Nazneen N. Dewji在他的关于presenilins蛋白的研究中指出这些蛋白是如何激发导致beta淀粉样蛋白产生的级联反应，从而引发AD。Nazneen N. Dewji指出PS蛋白的结构支持两个相连脑细胞表面反应的模型。Iftach Dolev 和 Daniel M. Michaelson研究了apolipoprotein E的亚型apoE4。他们关于老鼠中 beta淀粉样蛋白的核化、生长及逆转的研究应该能给了解该基因在AD中的作用带来曙光。
Vincenzo Solfrizzi其他作者一起综述了碳水化合物、蛋白质和脂肪及其基本成分在AD发展中的可能作用。他们建议饮食健康、服用抗氧化剂及预防营养缺乏 或者减少摄入高含量金属的事物和水，这是预防降低认知发生和进展首要因素。
最后的文章里，Jose L. Domingo集中讨论铝、铜和锌在AD中的作用，也讨论了金属螯合剂在治疗AD中的潜在作用。他们也综述了铝、铜和锌螯合剂在beta淀粉样蛋白斑块中的作用。
原文引用：
http://www.medicalnewstoday.com/medicalnews.php?newsid=57053
The Role Of Metals In Alzheimer's Disease Explored
Alzheimer's disease (AD) is a devastating condition and its causes are still largely unknown. Various metals have been implicated as possible contributors to the development of AD. In a special double issue of the Journal of Alzheimer's Disease published in November 2006, guest editors Andrei C. Miu and Oana Benga have brought together 14 insightful articles that explore the roles that metals play in the biochemistry and physiology of AD.
The articles cover six major categories: Comprehensive historical reviews, methodological perspectives, a topical review, integrative genetic and epigenetic reports, a review of risk factors and a "benchmark to clinical" review.
From guest editors Andrei C. Miu and Oana Benga: "We are grateful to the authors who accepted our challenge and who have shown that metallobiologists working in AD research have been less fascinated with describing end-stage pathognomonic lesions, and more concerned with identifying risk and aggravating factors that might help us better predict, diagnose and hopefully prevent AD in the future."
John Savory, Mary M. Herman and Othman Ghribi review the four-decades-old controversy about aluminum neurotoxicity, examining data on the possible cellular mechanisms underlying aluminum neurotoxicity and potential neuroprotective strategies against aluminum toxicity. In the next review, Paul A. Adlard and Ashley I. Bush discuss how metal ions such as zinc and copper can potentiate Alzheimer's disease by participating in the aggregation of normal cellular proteins and in the generation of reactive oxygen species. In the third review article, Arezoo Campbell focuses on how aluminum and copper can initiate or propagate an inflammatory response in the aging brain. Christopher Exley reviews in-vitro studies of metals found in plaque cores in AD brains and concludes that aluminum and iron could cause oxidative damage but copper and zinc likely do not. In the final review article, Andrei C. Miu and Oana Benga recount the long history of aluminum's hypothetical role in AD. They extensively discuss several lines of evidence for involvement of aluminum as a secondary aggravating factor or risk factor and argue that further studies are warranted.
Bettina Platt discusses the methodologies that have been used to identify Alzheimer- and dementia-related targets for exogenous toxins. She explains how neuronal function can be assessed experimentally, based on the evidence obtained for the neurotoxin aluminum. In the second article on methods, Joanna Collingwood and Jon Dobson write about recent approaches to locate and identify iron compounds in neurodegenerative tissue. In addition to complementary techniques that allow them to quantify and identify iron compounds using magnetometry, extraction and electron microscopy, they utilize a powerful combined mapping/characterization approach with synchrotron X-rays.
The movement of metals across the blood-brain barrier is reviewed by Robert A. Yokel. A number of transporters are described that could mediate metal transport into and out of the brain. He reviews the role of these transporters in moving aluminum, manganese, iron and other metals across the blood-brain barrier.
Hani Atamna has developed a novel model of amyloid-beta induced heme-deficiency that could account for neurodegeneration in AD patients. He reviews the genetic, nutritional and toxicological factors that influence heme metabolism and their relevance to AD. James R. Connor and Sang Y. Lee discuss genetic mutations in the HFE gene that can affect iron balance in the brain, potentially leading to the generation of reactive oxygen and oxidative damage. In a study of the presenilins (PS), Nazneen N. Dewji discusses how these proteins can trigger a cascade of processes that lead to amyloid-beta production, leading to AD. He reviews the structures of the PS proteins that can support the model of a surface reaction between two nearby brain cells. Iftach Dolev and Daniel M. Michaelson write about the apoE4 isoform of apolipoprotein E. Their study of the nucleation, growth and reversibility of amyloid-beta deposition in mice should shed new light on this genetic risk factor for AD.
Vincenzo Solfrizzi and co-authors review the possible role of macronutrients and the basic elements of carbohydrates, proteins, and fat in the development of AD. They suggest that healthy diets, antioxidant supplements, and the prevention of nutritional deficiencies or exposure to foods and water with high content of metals could be considered the first line of defense against the development and progression of cognitive decline.
In the final article, Jose L. Domingo focuses on the role of aluminum and metals such as copper and zinc in AD, as well as on metal chelator therapy as a potential treatment for AD. The effects of aluminum, copper and zinc chelating agents on amyloid-beta plaques are reviewed.
背景知识：
Pubmed OMIM：ALZHEIMER DISEASE
#104300
ALZHEIMER DISEASE; AD
ALZHEIMER DISEASE, FAMILIAL, 1, INCLUDED; AD1, INCLUDED
Gene map locus 20p, 19p13.2, 17q23.1, 17q23, 17q11.2, 12p11.23-q13.12, 12p13.3-p12.3, 10q24, 10q24, 7q36, 7q36, 7q36, 4p14
相关报道：
研究表明：红酒可治疗阿尔茨海默病
P-糖蛋白缺乏可增加阿尔茨海默病β-淀粉样物沉积
反义分子治疗阿尔茨海默病等疾病
无创光学工具有助于早期检测阿尔茨海默病
阿尔茨海默病非侵入性诊断试剂在美问世
白日梦与阿尔茨海默病相关？
ACE基因多态性与阿尔茨海默病的风险相关
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编辑简介：
1．Oana Benga
the Program of Cognitive Neuroscience, Department of Psychology, Babes-Bolyai University, Cluj-Napoca
主要文献：
Title : The Brain as We Know It
Description : Sophomore students will present various aspects of brain structure and functions to preschool and school children from Cluj-Napoca, Romania. The presentations will be brief, highly accessible to children, and as interactive as possible so as to maximize the knowledge acquired by children.
Date/time : 14 - 18 March 2005
Location : Cluj-Napoca
Audience : Primary, Secondary
Organised by: Program of Cognitive Neuroscience, Department of Psychology, Babes-Bolyai University
Main Contact: Oana Benga and Andrei Miu
Contact phone number: +40-264-590967
Address: 37 Republicii Street, Cluj-Napoca, CJ 400015, Romania
Title : Neuroscience in the Albert Einstein Year: event series
Description : The program will include 2 lectures that are intended to familiarize the general public with recent advances in neuroscience: "Pheromones and Sexual Behavior" (Dr. Alina Rusu); and "The Neurobiological Basis of Personality" (Dr. Adrian Opre). Another lecture will mark the International Albert Einstein Year: "What do bigger brains mean in development and evolution?" and "Allometry and the Brain of Albert Einstein" (Andrei Miu).
Date/time : 16 March 2005; 17:00 - 20:00
Location : Europa International Centre of Congress and Conference, 1-3 Lucian Blaga Square, Cluj-Napoca, Romania
Audience : General Public, Professionals, University
Organised by: Program of Cognitive Neuroscience, Department of Psychology, Babes-Bolyai University
Main Contact: Oana Benga and Andrei Miu
Contact phone number: +40-264-590967
Address: 37 Republicii Street, Cluj-Napoca, CJ 400015, Romania
Title : An Introduction to Applied Neuroscience: Behavioral Neuroscience
Description : Several activities intended to familiarize the public with the applications of neuroscience and some of the methods used in behavioral neuroscience: laboratory demonstrations, slide projections, posters presented by junior students on a wide variety of topics.
Date/time : 18 March 2005; 15:00 - 20:00
Location : Faculty of Psychology and Educational Sciences, 7 Sindicatelor Street, Cluj-Napoca, Romania
Audience : General Public, University, Secondary
Organised by: Program of Cognitive Neuroscience, Department of Psychology, Babes-Bolyai University
Main Contact: Oana Benga and Andrei Miu
Contact phone number: +40-264-590967
Address: 37 Republicii Street, Cluj-Napoca, CJ 400015, Romania
Title : High School Essay Contest: How Our Brains Become Who We are?
Description : Short essay contest for high school pupils. The contest will be widely announced in all highschools from Cluj-Napoca. The essays must be addressed to Dr. Oana Benga, 37 Republicii Street, Cluj-Napoca, CJ 400015, Romania.
Date/time : 20 March 2005 (Deadline)
Location : Institute of Psychology, 37 Republicii Street, Cluj-Napoca, CJ 400015, Romania
Audience : Secondary
Organised by: Program of Cognitive Neuroscience, Department of Psychology, Babes-Bolyai University
Main Contact: Oana Benga and Andrei Miu
Contact phone number: +40-264-590967
Address: 37 Republicii Street, Cluj-Napoca, CJ 400015, Romania
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2．Andrei C. MIU
Andrei C. MIU, B.A., M.Sc. (Med.)
Programul de Neurostiinte Cognitive
Universitatea Babes-Bolyai
Str. Republicii, nr. 37, Cluj-Napoca, CJ 400015, Romania
Pregatire si pozitii profesionale
2006-prezent Asistent universitar, titular al seminariilor la disciplinele Neuropsihologie, Psihologie Cognitiva; lector delegat pentru cursul de Neuropsihologie.
2003-prezent Doctorand in Psihologie (stagiul doctoral incheiat, in faza de redactare a tezei de doctorat), Universitatea Babes-Bolyai, Cluj-Napoca.
Teza de doctorat: Emotie si cognitie: Lateralizare cerebrala, diferente individuale si de gen. Coord. St: Prof. Univ. Dr. Mircea Miclea.
2001-2006 Tutore la disciplinele Neurofiziologie, Neuropsihologie, Psihologie Cognitiva
2005 Master in Medicina Moleculara si Neurostiinte, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca.
2003 Licentiat in Psihologie (Sef de Promotie), Universitatea Babes-Bolyai, Cluj-Napoca.
1999 Bacalaureat (cu nota 10) al Colegiului National Ion C. Bratianu, Pitesti.
Stagii de preGATIRE PROFESIONALA
2000 Absolvent al Development and Cognition, Universitatea Babes-Bolyai, Cincis, Romania.
2001 Absolvent bursier al 8th Summer School of Cognitive Science, Central and Eastern European Center of Cognitive Science, Sofia, Bulgaria (Credite obtinute la cursul Development and Evolution of the Brain al Prof. Dr. Barbara L. Finlay, Cornell University, Ithaca, SUA).
2005 Absolvent bursier al Development and Plasticity of the Human Cerebral Cortex, IBRO/FENS si Croatian Institute for Brain Research, Zadar/Zagreb, Croatia.
2006 Absolvent bursier al John Merck Summer Institute on the Biology of Developmental Disorders, Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, Princeton, SUA.
Domenii de expertiza in cercetare:
- neurostiinte cognitive si clinice; psihofiziologia emotiei si cognitiei; neurobiologia imbatranirii normale si patologice.
Abilitati de cercetare:
- leziuni stereotaxice in creier la rozatoare mici de laborator;
- evaluarea comportamentala a rozatoarelor mici de laborator;
- analiza histologica si ultrastructurala a tesutului nervos in conditii normale si patologice;
- inregistrarea si analiza cantitativa a rezistentei electrice a pielii si electrocardiogramei in cercetari psihofiziologice.
Membru in asociatii profesionale
2004-prezent Membru al International Brain Research Organization (IBRO).
2005-prezent Membru al Societatii Nationale de Neurostiinte (SNN).
2005-prezent Membru afiliat al Federation of European Neuroscience Societies (FENS).
2005-prezent Membru al Asociatiei Psihologilor din Romania (APR).
2006-prezent Membru al Cognitive Neuroscience Society (CNS).
2006-prezent Membru al International Association for Research in Economic Psychology (IAREP).
2006-prezent Membru al Society for Advancement for Behavioral Economics (SABE).
Distinctii stiintifice
1997, 1999 Premii si Mentiuni multiple la fazele nationale ale olimpiadelor de stiinte, inclusiv laureat al fazei nationale a Olimpiadei de Psihologie, Resita.
2002 Premiu al Societatii Romane de Stiinte Fiziologice (SRSF).
2003 Premiul Asociatiei Editorilor din Romania (AER) pentru Cea mai Buna Carte de Biologie (pentru vol. I din Neurostiinte. De la mecanisme moleculare si celulare la comportament si evolutie; Editura Dacia, 2002).
2003 Premiu al Universitatii de Medicina si Farmacie Iuliu Hatieganu, pentru lucrare stiintifica prezentata in cadrul Zilelor UMF Iuliu Hatieganu.
2003 Premiu acordat prin concurs international de catre FENS pentru participarea la 4th FENS Forum of Neuroscience.
2005 Premiu acordat prin concurs international de catre IBRO/FENS pentru participarea la scoala de vara Development and Plasticity of the Human Cerebral Cortex.
2006 Premiu al Societatii Nationale de Neurostiinte (SNN).
Prelegeri invitate
2000 Neurogeneza in creierul adult: Revolutie sau revelatie?, Asociatia Studentilor in Psihologie din Transilvania, Cluj-Napoca.
2002 Prelucrarea datelor statistice in neurofiziologie, cursul postuniversitar Tehnici standard de conducere nervoasa, Clinica de Neurologie Ion Minea, Universitatea de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca.
2005 Behavioral Neuroscience and Brain Lesion Studies, Coneural Cluj-Napoca si Frankfurt Institute for Advanced Studies & Max Planck Institute for Neurobiology, Cluj-Napoca.
2005 Corpus Callosum Transection and Environmental Enrichment in Adult Rats, minisimpozionul Ecology, Ethology, and Evolution, organizat de Programul de Neurostiinte Cognitive, Catedra de Psihologie, Universitatea Babes-Bolyai si Universitatea din Zürich, Cluj-Napoca
2005 Allometry and the Brain of Albert Einstein, in cadrul Saptamanii Cunoasterii Creierului in Cluj-Napoca, Programul de Neurostiinte Cognitive, Catedra de Psihologie, Universitatea Babes-Bolyai, ca partener al European Dana Alliance for the Brain, Cluj-Napoca.
2005 Balanta simpato-vagala si variatia frecventei cardiace in anxietate, in cadrul celui de-Al 2-lea Simpozion al Societatii Nationale de Neurostiinte, Universitatea de Medicina si Farmacie Gr. T. Popa, Iasi.
2006 Neuroscience of Music: How the Brain Processes Music, in cadrul Saptamanii Cunoasterii Creierului in Cluj-Napoca, Programul de Neurostiinte Cognitive, Catedra de Psihologie, Universitatea Babes-Bolyai, ca partener al European Dana Alliance for the Brain, Cluj-Napoca.
2006 Corpus Callosum Transection in Rats: Neuroplasticity and Behavioral Effects, 2nd International Conference of the National Neuroscience Society of Romania, Biblioteca Academiei Romane, Bucuresti.
Activitate editoriala si consultanta stiintifica
2002-prezent Consultant stiintific (Neurostiinte) pentru emisiunea „Magazin Stiintific”, BBC Romania.
2003-prezent Editor Asociat, Journal of Alzheimer’s Disease (IOS Press, Olanda).
2004-prezent Membru al International Board of Reviewers, Medical Science Monitor (Medical Science International Ltd., SUA).
2004-prezent Asociat (ales de Colegiul Editorial) al Behavioral and Brain Sciences (Cambridge University Press, USA).
2005-prezent Membru in Colegiul Editorial, Cognitie, Creier, Comportament (Asociatia de Stiinte Cognitive din Romania).
Recenzor ad-hoc (reviste ISI)
Journal of Alzheimer’s Disease, Neuropathology and Applied Neurobiology, Journal of Cognitive Neuroscience, Neuropsychologia.
Manifestari stiintifice (Organizator):
Saptamana Cunoasterii Creierului in Cluj-Napoca, 2005, 2006. Organizata de Programul de Neurostiinte Cognitive, Catedra de Psihologie, Universitatea Babes-Bolyai, in parteneriat cu European Dana Alliance for the Brain (EDAB).
Publicatii stiintifice (peste 20 de citari in Citation Index)
Carti in Romania
A. C. Miu & A. I. Olteanu (2002). Neurostiinte – De la mecanisme moleculare si celulare la comportament si evolutie. Vol. I: Dezvoltarea sistemului nervos. Cluj-Napoca: Editura Dacia, 231 pp. (Cu o Prefata de Prof. Dr. Luis Puelles, University of Murcia, Spania; 9 recenzori internationali).
A. Olteanu, V. Lupu, & A. Miu (2001). Neurofiziologia comportamentului uman. Cluj-Napoca: Presa Universitara Clujeana, 214 pp. (Cu o Prefata de Prof. Dr. Mircea Miclea, Universitatea Babes-Bolyai, Romania).
Volume editate in Romania (indexate in baze de date internationale)
O. Benga & A. C. Miu (2005). Developmental cognitive neuroscience. Cluj-Napoca: Editura ASCR (Numar special al Cognitie, Creier, Comportament/Cognition, Brain, Behavior, revista oficiala a Asociatiei de Stiinte Cognitive din Romania).
Volume editate in strainatate si cotate ISI (ca editor invitat)
A. C. Miu & O. Benga (2006, sub tipar). Metallotoxicity in Alzheimer’s disease. Amsterdam: IOS Press.
Volume ingrijite
J. B. Hellige & J. E. Bogen (Eds.) (2006). Brain Asymmetry in Development, Psychopathology, and Evolution. Cluj-Napoca: Editura ASCR (Numar special al Cognitie, Creier, Comportament/Cognition, Brain, Behavior).
Capitole in volume colective din strainatate
A. C. Miu, A. Opre, M. Birt, V. Tibre, & A. I. Olteanu (2003). An Interhemispheric Paradigm for Asssessing Declarative Memory Deficits in Alzheimer’s Disease. A Neuropsychological and Structural Imaging Study. In: B. Kokinov, W. Hirst (Eds.), Constructive Memory (pp. 280-291). Sofia: NBU Series in Cognitive Science.
Capitole in volume colective din Romania
O. Benga, L. Petra, & A. Miu (2005). Corelate electrofiziologice ale dezvoltarii tipice si atipice. Perspectiva neurostiintelor cognitive ale dezvoltarii. In L. Zagrean (Red.): Neurofiziologie clinica (pp. 381-418). Bucuresti: Editura UMF Carol Davila.
A. Miu (2001). Structura si dezvoltarea temperamentului. In: B. Miu, M. Ivan, A. Ivan, F. Miu (Red.), Adolescentii si timpul liber (pp. 100-110). Pitesti: Editura Universitatii din Pitesti.
Traduceri
R. Morris & M. Filenz (2007, in pregatire). Neuroscience. Science of the Brain. International Brain Research Organization. (In colaborare cu S. P. Pasca)
Articole stiintifice
In pregatire, in curs de revizuire, sub recenzie
A. C. Miu, R. M. Heilman, A. Zlati, & D Houser (2006). A behavioral and psychophysiological study of trait anxiety in Iowa gambling task.
A. C. Miu, R. M. Heilman, & D. Houser (2006). Neuroeconomics: Is Trait Anxiety a Moderator of Reciprocal Fairness and Dorsolateral Prefrontal Cortex Activity?
P. M. Schalomon, S. D. Bury, & A. C. Miu (2006). Experience-dependent neural plasticity of the isocortex: What have we learned from corpus callosum transection?
In reviste internationale cotate ISI
A. C. Miu, R. M. Heilman, S. P. Pasca, C. Stefan, F. Spanu, R. Vasiu, A. i. Olteanu, M. Miclea (2006). Behavioral effects of corpus callosum transection and environmental enrichment in adult rats. Behavioural Brain Research 172, 135-144.
A. C. Miu & O. Benga (2006). Metallotoxicity in Alzheimer’s Disease. Journal of Alzheimer’s Disease 10(2-3), sub tipar.
A. C. Miu & O. Benga (2006). Aluminium and Alzheimer’s disease: A new look. Journal of Alzheimer’s Disease 10(2-3), sub tipar.
A. C. Miu (2006). The silicon link between aluminium and Alzheimer’s disease. Journal of Alzheimer’s Disease 10(1), 39-42.
A. C. Miu (2005). Asymmetrical behavior without an asymmetrical brain: Corpus callosum and neuroplasticity. Behavioral and Brain Sciences 28, 608-609.
S. P. Pasca, B. Nemes, L. Vlase, C. E. Gagyi, E. Dronca, A. C. Miu, M. Dronca (2005). High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sciences, 78, 2244-2248.
A. C. Miu, R. M. Heilman, A. Opre, & M. Miclea (2005). Emotion-induced retrograde amnesia and trait anxiety. Journal of Experimental Psychology: Learning, Memory, and Cognition 31, 1250-1257.
A. C. Miu, A. I. Olteanu, I. Chis, & R. M. Heilman (2004). Have no fear, erythropoietin is here: Erythropoietin protects fear conditioning performances after functional inactivation of the amygdala. Behavioural Brain Research 155, 223-229.
A. C. Miu, A. I. Olteanu, & M. Miclea (2003). A behavioral and ultrastructural dissection of the interaction of aluminium with aging. Journal of Alzheimer’s Disease 6, 315-328.
A. C. Miu, C. E. Andreescu, R. Vasiu, & A. I. Olteanu (2003). A behavioral and histological study of the effects of long-term exposure of adult rats to aluminum. International Journal of Neuroscience 113, 1197-1211.
A. C. Miu & A. I. Olteanu (2003). Reshuffling or inventing prosomeres: Expensive radiation or expensive neural tissue?. Behavioral and Brain Sciences 26, 564-565.
A. C. Miu & A. I. Olteanu (2002). Catatonia in Alzheimer’s disease: The role of the amygdalo-hippocampal circuits. Behavioral and Brain Sciences 25, 588-589.
C. Exley, A. C. Miu, et al. (2005). Aluminium and Camelford. British Medical Journal 330, 275-276.
In reviste romanesti (din care *indexate in baze de date internationale)
A. C. Miu, S. P. Pasca, A. I. Olteanu, & C. Craciun (2004). Fapte si artefacte despre neurotoxicitatea aluminiului. Analele Societatii Nationale de Biologie Celulara 9, 44-55.
*O. Benga & A. C. Miu (2005). Integrative neuroscience: The Special Case of development. Cognitie, Creier, Comportament 9, 191-192.
*A. C. Miu, S. P. Pasca, & M. Miclea (2005). The corpus callosum and the power of complementary paradigms in developmental cognitive neuroscience. Cognitie, Creier, Comportament 9, 423-450.
*A. Opre, A. C. Miu, & P. András (2005). Korsakoff’s amnesia and its relation to development. Cognitie, Creier, Comportament 9, 451-474.
*A. C. Miu, R. M. Heilman, R. A. Anton, C. Indrei, S. Braica, T. Krizsan, V. Tibre, & A. I. Olteanu (2003). A physiological and personological account of sympathovagal balance in controlled anxiety and relaxation. Cognitie, Creier, Comportament 7, 242-260.
A. C. Miu & A. I. Olteanu (2003). Secretia si actiunea eritropoetinei in sistemul nervos central. Clujul Medical LXXVI, 47-58.
*A. C. Miu, A. Opre, M. A. Birt, V. Tibre, & A. I. Olteanu (2003). Interhemispheric disconnection syndrome and white matter damage in Alzheimer’s disease: Neuropsychological tasks and contrastive case studies. Cognitie, Creier, Comportament 7, 133-148.
*A. C. Miu, R. I. Medrea, C. E. Andreescu, C. I. Stancu, N. Vlasie, & A. I. Olteanu (2003). Impaired recognition memory and emotional reactivity associated with loss of cortical integrity on rats after chronic exposure to aluminum. Cognitie, Creier, Comportament 7, 219-234.
A. C. Miu, C. Andreescu, R. Vasiu, & A. I. Olteanu (2002). Prolonged exposure to aluminum is associated with a progressive behavioral decline and neurodegeneration. Implications for Alzheimer’s disease. Clujul Medical LXXV, 671-677.
*A. Opre & A. Miu (2001). Sisteme mnezice multiple si constiinta: Un model neurocognitiv. Cognitie, Creier, Comportament 5, 193-219.
V. Lupu, S. Boros, A. Miu, F. Iftene, & A. Geru (2001). Jocul patologic de noroc la adolescentii romani. Revista Societatii de Neurologie si Psihiatrie pentru Copii si Adolescenti din Romania 4, 201-214.
*A. Olteanu & A. Miu (2000). Neurogeneza in creierul adult. Cognitie, Creier, Comportament 4, 213-223.
A. Olteanu, G. Cardei-Martinescu, A. Miu, V. Lupu, & L. Plesca-Manea (2000). Efectele Piracetamului asupra accesarii si consolidarii mnezice. Noutati Medicale 8, 47-52.
*A. Olteanu, A. Miu, M. Cipleu, & V. Lupu (2000). Influente modulatoare asupra invatarii si memoriei. Cognitie, Creier, Comportament 5, 347-365.
C. Craciun, A. I. Olteanu, A. C. Miu, R. Mansat-Silasi, L. Barbu-Tudoran, P. A. Darau (2004). Studii structurale si ultrastructurale privind efectul intoxicatiei cu aluminiu la nivelul ficatului de sobolan. Analele Societatii Nationale de Biologie Celulara, 9, 62-69.
Lucrari citate recent in reviste si carti ISI:
Physiology and Behavior 85, 159-166.
Psychological Review 111, 984-1002.
Life Sciences 77, 140-148.
Medical Hypotheses 64, 960-967.
Journal of Alzheimer’s Disease 9 (1-2), sub tipar.
Vortrag vor dem Plenum der Leibniz-Societät 1, 1-8.
Behavioral and Brain Sciences 25, 555-577.
Behavioral and Brain Sciences 26, 535-586.
Neuropathology 25, 195-200.
Neurotoxicology 27 (4): 451-457 JUL 2006
Biometals 19 (1): 83-89 FEB 2006
Toxicology 219 (1-3): 1-10 FEB 15 2006
Toxicology 218 (2-3): 112-124 FEB 1 2006
Neurochemistry International 49 (3): 238-244 AUG 2006
Neurotoxicology 27 (3): 402-408 MAY 2006
Histology and Histopathology 21 (2): 131-140 FEB 2006
Biochimica et Biophisica Acta – General Subjects 1725 (3): 327-339 OCT 10 2005
Journal of Neuroscience 26 (7): 2072-2079 FEB 15 2006
Toxicological Sciences 2006, 92(2), 500–506.
Autoimmunity Reviews (2006), in press
Human Molecular Genetics, 2006, Vol. 15, Review Issue No. 2 R138–R150.
Lucrari citate recent in carti ISI (selectiv):
C. Exley in R. Harris, F. Fahrenholtz (Red.), Alzheimer’s Disease: Cellular and Molecular Aspects of Amyloid Beta (pp. 225-234). Berlin: Springer Verlag.
Lucrari citate recent in rapoarte guvernamentale
Raport al Food and Drug Administration, SUA, octombrie 2005.
Lucrari citate recent in reviste internationale neindexate ISI (selectiv):
Chinese Journal of Industrial Hygiene and Occupational Diseases 23, 132-135.
Revista de la Faculdad de Medicina (Caracas) 27, 119-124.
Granturi nationale
In curs de evaluare
Corelate psihofiziologice ale procesarii emotionale in memorie si decizie. Remis spre evaluare in competitia CNCSIS 2006.
Finalizate sau in derulare
2004-2005 Grant CNCSIS E, Dezvoltarea infrastructurii de cercetare a Laboratorului de Neurostiinte Cognitive al Centrului de Psihologie Cognitiva Aplicata. Director: Prof. Univ. Dr. Mircea Miclea.
2004-2006 Grant CNCSIS A, Studii structurale si functionale asupra impactului intoxicatiei cu aluminiu pe organe vitale. Director: Prof. Univ. Dr. Constantin Craciun.
2006 Grant CEEX ET, Traiectorii de dezvoltare si corelate neurobiologice ale procesarilor cognitiv-emotionale in populatii normale sau atipice. Director: Conf. Univ. dr. Oana Benga, nr. 54.
2006-2007 Grant CEEX ET, Perioade critice in dezvoltarea functiilor executive. Director grant: Conf. Univ. dr. Oana Benga, nr. 131.
2006-2008 Grant CEEX, Analiza neurocognitiva si developmentala a anxietatii: Aplicatii in optimizarea metodelor de diagnoza si psihoterapie. Director: Prof. Univ. Dr. Mircea Miclea.
Rezumate publicate in volumele unor conferinte
A. C. Miu & S. Boros (2000). Identity and Psychosocial Stress in Postcommunist Romania. Proceedings of Stressful Changes: Psychological Aspects of Postcommunist Transformations, Cluj-Napoca.
V. Lupu, S. Boros, A. C. Miu, F. Iftene, & A. Geru (2001). Pathological gambling in Romanian teenagers. Proceedings of Psychopathology and Neuropathology of Teenagers, Bucuresti.
A. Olteanu, A. C. Miu, C. Andreescu, & R. Vasiu (2001). The validation of an animal experimental model of Alzheimer disease through aluminium overload. Proceedings of the Symposium of the 8th International Summer School of Cognitive Science, Sofia.
A. C. Miu & A. Opre (2001). Multiple memory systems and consciousness: A neurocognitive approach. Proceedings of the Symposium of the 8th International Summer School of Cognitive Science, Sofia.
C. Andreescu, A. C. Miu, R. Vasiu, & A. Olteanu (2001). Dovezi morfopatologice pentru medierea hepatica a neurotoxicitatii aluminiului. Volumul de rezumate al Zilelor Universitatii de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca.
A. C. Miu, C. Andreescu, R. Vasiu, & A. Olteanu (2001). Modificari comportamentale si neuropatologice produse de aluminiu la sobolani. Volumul de rezumate al Zilelor Universitatii de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca.
A. C. Miu, C. Andreescu, R. Vasiu, & A. I. Olteanu (2002). The Role of Aluminum in the Pathogenesis of Alzheimer-like encephalopathy. In: A. Muresan, Orasan, R. (Red.): Stresul oxidativ in procese fiziologice si patologice. Editura Medicala Universitara Iuliu Hatieganu, Cluj-Napoca.
A. C. Miu & A. I. Olteanu (2002). An Ethological Analysis of the Open-Field Test: The Effects of Chlorpromazine and Amphetamine. In: A. Muresan, Orasan, R. (Red.): Stresul oxidativ in procese fiziologice si patologice. Editura Medicala Universitara Iuliu Hatieganu, Cluj-Napoca.
A. C. Miu, A. I. Olteanu, C. Craciun, & L. Barbu-Tudoran (2003). Impaired recognition memory and emotional reactivity correlated with mitochondrial atrophy and myelin shrinking in the hippocampus of adult rats with aluminum-induced encephalopathy. Proceedings of Developmental Cognitive Neurosciences – Integrative Perspectives, Cluj-Napoca.
A. C. Miu, A. Opre, & A. I. Olteanu (2003). Neuropsychological and structural neuroimaging evidence for a contribution of white matter damage to declarative memory deficits on Alzheimer`s disease. Proceedings of Developmental Cognitive Neurosciences – Integrative Perspectives, Cluj-Napoca.
R. Heilman, C. Indrei, R. A. Anton, T. Krizsan, S. Braica, C. I. Stancu, S. Ioja, D. Turturica, R. I. Medrea, A. C. Miu, V. Tibre, & A. I. Olteanu (2003). Sympathovagal balance in the nonlinear control of heart rate variability in experimentally-controlled anxiety. Proceedings of Developmental Cognitive Neurosciences – Integrative Perspectives, Cluj-Napoca.
R. I. Medrea, A. C. Miu si A. I. Olteanu (2003). Histological assessment of cortical integrity on aluminum-induced encephalopathy. A Bielchowsky silver stain study. Proceedings of Developmental Cognitive Neurosciences – Integrative Perspectives, Cluj-Napoca.
A. C. Miu, A. I. Olteanu, I. Chis, & R. M. Heilman (2004). Erythropoietin protects fear conditioning performances against functional inactivation of the amygdala in rats. Abstracts of the 4th Forum of European Neuroscience, Lisabona.
A. C. Miu, A. I. Olteanu, C. Craciun, & L. Barbu-Tudoran (2004). Aging is a moderator of the neurotoxicity of aluminum in the hippocampus: An evaluation of myelin and mitochondrial atrophy. Buletinul Societatii Nationale de Biologie Celulara, Sighisoara.
A. C. Miu, I. Chis, R. M. Heilman, & A. I. Olteanu (2004). Eritropoetina protejeaza neuronii amigdalieni impotriva neurotoxicitatii glutamatului. Volumul de rezumate al Zilelor Universitatii de Medicina si Farmacie Iuliu Hatieganu, Cluj-Napoca.
A. C. Miu, A. I. Olteanu si M. Miclea (2004). Neurotoxicitatea aluminiului in hipocampul senescent: Atrofia mitocondriilor si a mielinei. Volumul de rezumate al Zilelor Universitatii de Medicina si Farmacie Iuliu Hatieganu,Cluj-Napoca.
A. C. Miu (2005). Corpus callosum transection and environmental enrichment in adult rats. In: Development and Plasticity of the Human Cerebral Cortex. Zadar/Zagreb: HIIM.
A. C. Miu, N. Giurgea, & A. I. Olteanu (2005). Balanta simpato-vagala si variatia frecventei cardiace in anxietate. Volumul de Rezumate al celui de-Al Doilea Simpozion al SNN Stresul – Investigare, Atitudine, Perspective, Iasi.
A. C. Miu & A. I. Olteanu (2005). Atrofia corpului calos si sindromul de disconectie in imbatranire si boala Alzheimer. Volumul de rezumate al Conferintei Nationale de Geriatrie si Gerontologie Imbatranire Biologica – Imbatranire Patologica, Cluj-Napoca.
