敌意、发火和沮丧这些糟糕的情绪变化似乎不是那么可怕，但它们可能会对我们的健康带来一些负面影响，比如说心脏病、糖尿病和高血压。
《大脑行为与免疫》（Brain Behavior and Immunity）是爱思唯尔出版集团旗下的一份期刊。在最新出版的一期中，研究者介绍了如下试验：313名男子参加了一项空军健康研究项目，旨在测定敌意、发火和沮丧这些情绪变化是否会引起人体内C3蛋白含量的变化。C3蛋白质是控制油脂和葡萄糖代谢的一种主要蛋白，和心血管疾病以及糖尿病有关。这类体检连续进行了20年，研究者根据有关测验收集到所需要的信息，然后对他们的个性特征、心理因素以及罹患各种慢性疾病的风险进行评估。在1992、1997和2002三个年份中，研究者还对受试者体内的C3蛋白和C4蛋白进行了评估。
根据对这些中年健康男性的长时间研究，研究者发现，对敌意、发火和沮丧等情绪变化的测定，很好地预测了10年中C3蛋白的增加趋势。他们认为，这些数据有力地佐证了如下的规律：情绪，比如敌意、发火和沮丧，是和长期的炎症形成过程息息相关，而炎症会导致冠状心脏病、糖尿病和高血压。
总而言之，当危及到健康时，我们就应该对敌意、发火和沮丧的情绪进行快速的调整。否则，长期下来，我们就可能因此而倒霉了。
部分英文原文：
Brain, Behavior, and Immunity, In Press, Corrected Proof, Available online 23 February 2007,
Hostility, anger, and depression predict increases in C3 over a 10-year period
Stephen H. Boylea, , , William G. Jacksonb and Edward C. Suareza, ,
aDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, P.O. Box 3328, Durham, NC 27710, USA
bAir Force Research Laboratory Brooks-City Base, TX, USA
Received 30 June 2006; revised 9 January 2007; accepted 12 January 2007. Available online 23 February 2007.
Abstract
We examined the relation of hostility, anger, and depression to 10-year changes in the third (C3), and fourth (C4) complement in 313, apparently healthy male participants enrolled in the Air Force Health Study (AFHS), a 20-year study designed to evaluate the health consequences of dioxin exposure. Hostility, depression, and anger were assessed using subscales from the Minnesota Multiphasic Personality Inventory (MMPI), which was administered in 1985. Given the high intercorrelations among these psychological scales, we used a principal component analysis to generate a composite score representing the linear combination of the hostility, anger, and depression scales. The dependent variables, C3 and C4 levels, were determined from samples collected in 1992, 1997, and 2002. Regression analyses controlling for age, race, alcohol use, body mass index, and cigarette use as well as onset of disease, and use of lipid lowering and blood pressure medications during follow-up revealed a significant time × composite score interaction for C3 complement (p < .0003), but not C4. Post-hoc analyses revealed that high composite scores were associated with larger 10-year increases in C3. These observations suggest that men who are hostile and are prone to experience frequent and intense feelings of anger, and depression show activation of the complement system, and specifically increases in C3, that may contribute to the development of coronary heart disease.
Keywords: Complement; Hostility; Anger; Depression; Men
Corresponding authors. Fax: +1 919 668 6419.
