在一项新的动物研究中，密西根大学的研究人员表示，在暴露于噪音前一个小时，服用维生素A、C、和E及镁的大剂量组合，并且每天服用一次连续服用五天，对于防止噪音造成的听力永久损失，是相当有效的。
这种听力保护药片或点心，将会很快地进行人体的临床试验，如果这种产品的临床试验成功，将于二年内上市。这篇研究发表于Free Radical Biology and Medicine中。
研究作者Josef M. Miller表示，许多研究证据显示，营养素可以阻止噪音造成的听力丧失，噪音会使得内耳的自由基活性过高而造成听力损失。氧自由基与噪音伤害有关。噪音暴露后，氧自由基释放至毛细胞，并转变为极具破坏力的氢氧自由基。因此噪音暴露后，抗氧化物可以预防暂时性听力损失。
这项研究结果建议，无法避免暴露于噪音环境中的人们，例如军人、飞行员、建筑工人等，可以在早上接受这种多合一营养补充法的治疗，使听力损伤减到最小。
(资料来源 : Bio.com)
英文原文：
Public release date: 28-Mar-2007
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Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Nutrients might prevent hearing loss, new animal study suggests
Antioxidant-mineral combination protects against damage for days after noise exposure, U-M study in guinea pigs shows
This release is available in Spanish.
Colleen Le Prell and Josef M. Miller, the lead and senior authors of new research on the use of nutrients to prevent hearing loss in guinea pigs.
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ANN ARBOR, Mich. -- Soldiers exposed to the deafening din of battle have little defense against hearing loss, and are often reluctant to wear protective gear like ear plugs that could make them less able to react to danger. But what if a nutritious daily "candy bar" could prevent much of that potential damage to their hearing?
In a new study in animals, University of Michigan researchers report that a combination of high doses of vitamins A, C, and E and magnesium, taken one hour before noise exposure and continued as a once-daily treatment for five days, was very effective at preventing permanent noise-induced hearing loss. The animals had prolonged exposure to sounds as loud as a jet engine at take-off at close range.
Clinical trials of a hearing-protection tablet or snack bar for people could begin soon, and if successful such a product could be available in as little as two years, says Josef M. Miller, Ph.D., the senior author of the study, which is published online in the journal Free Radical Biology and Medicine. Miller is a professor in the Department of Otolaryngology at the U-M Medical School, and former director of the U-M Health System抯 Kresge Hearing Research Institute, where the study was performed.
Convinced by emerging evidence that nutrients can effectively block one major factor in hearing loss after noise trauma ?inner ear damage caused by excessive free radical activity ?Miller has launched a U-M startup company OtoMedicine that is developing the vitamin-and-magnesium formulation.
"These agents have been used for many years, but not for hearing loss. We know they抮e safe, so that opens the door to push ahead with clinical trials with confidence we抮e not going to do any harm," says Miller.
The formulation the researchers used built on earlier animal studies showing that single antioxidant vitamins were somewhat effective in preventing hearing loss, and on studies of Israeli soldiers given magnesium many days prior to exposure, who gained relatively small protective effects.
In the U-M study, noise-induced hearing loss was measured in four groups of guinea pigs treated with the antioxidant vitamins A, C and E, magnesium alone, an ACE-magnesium combination, or a placebo. The treatments began one hour before a five-hour exposure to 120 decibel (dB) sound pressure level noise, and continued once daily for five days.
The group given the combined treatments of vitamins A, C and E and magnesium showed significantly less noise-induced hearing loss than all of the other groups.
"Vitamins A, C and E and magnesium worked in synergy to prevent cell damage," explains Colleen G. Le Prell, Ph.D., the study抯 lead author and a research investigator at the U-M Kresge Hearing Research Institute. According to the researchers, pre-treatment presumably reduced reactive elements called free radicals that form during and after noise exposure and noise-induced constriction of blood flow to the inner ear, and may have also reduced neural excitotoxicity, or the damage to auditory neurons that can occur due to over-stimulation. The post-noise nutrient doses apparently "scavenged" free radicals that continue to form long-after after this noise exposure ends.
In the past 10 years, scientists have learned that noise-induced hearing loss occurs in part because cell mitochondria in the ear churn out damaging free radicals in response to loud sounds. "Free radical formation bursts initially, then peaks again during the days after exposure," explains Le Prell.
The antioxidant vitamins and magnesium used in the study are widely used dietary supplements, not new drugs, and therefore they don抰 require the extensive safety tests required for new drug entities prior to use in clinical trials. The doses to be used in proposed human trials will be within the ranges considered safe according to the Institute of Medicine and federal nutrition guidelines.
"Ultimately, we envision soldiers would have a nutritional bar with meals and it would give them adequate daily protection," says Miller. Similar bars with other formulations are already given to soldiers to help them withstand hot weather and other war zone conditions.
"Other people would likely benefit by consuming a pill or nutritional bar before going to work in noisy environments, or attending noisy events like NASCAR races or rock concerts, or even using an iPod or other music player," says Le Prell. "Based on an earlier study with other antioxidant agents, we think this micronutrient combination will work even post-noise."
That study suggested a "morning after" treatment, that might minimize hearing damage for soldiers, musicians, pilots, construction workers and others ?even if they don抰 take it until after they experience dangerous noise levels. It was highlighted by the National Institutes of Health on the NIDCD website at www.nidcd.nih.gov/research/stories/archives/06/08_01_06.asp.
If effective, such pre- and post-noise treatments could have far-reaching effects. About 30 million Americans regularly experience hazardous noise levels at work and at home, according to the National Institute on Deafness and Communications Disorders. Hunting, snowmobiling, using machines such as leaf blowers, lawnmowers and power tools, and attending or playing in loud music concerts commonly expose people to dangerous noise levels. Noise levels above 85 decibels damage hearing. About 28 million Americans have some degree of hearing loss. For about a third of them, noise accounts at least in part for their loss.
The U-M study also adds strength to research efforts under way in many research centers to learn how these nutrients might be used to treat many illnesses. "Similar combinations have been very effective in preventing macular degeneration, and many of these agents have been used with Alzheimer抯 and Parkinson抯 diseases, stroke-like ischemia, and other conditions that involve neural degeneration," Le Prell says. "You抮e always hoping as a basic scientist to find a commonality like that, across other disease processes," says Miller.
U-M has applied for patents covering the use of this unique combination of vitamins and minerals in the prevention of hearing loss, as demonstrated in this study; if and when revenues are generated as a result of these commercialization efforts, the University and the inventors of the technology stand to benefit financially. An additional author of the study is Larry F. Hughes, Dept. of Surgery/Otolaryngology, Southern Illinois University Medical School. The study was supported with funds from the National Institutes of Health, General Motors Corporation/United Automotive Workers Union, and the Ruth and Lynn Townsend Professorship in Communication Disorders. Reference: Free Radical Biology & Medicine, 42 (2007) 1454?463
