感觉信息是通过大脑对运动与感觉之间的协调互动作用来进行采集与处理的。Ferezou研究小组利用电压敏感染料直接对小鼠的躯体感觉和相应的大脑感觉运动皮层进行成像。这项研究首次提供了大脑皮层对感觉运动的综合图像,揭示了高度动态和分布式处理过程与躯体行为的关联。相关论文以封面文章的形式发表在2007年12月6日的《神经元》(Neuron)上。
躯体感觉往往源于触摸物体时主动产生的躯体运动,而感觉信息则是用来改进和控制这些运动。因此,在感觉与运动相互作用之间必然有一个重要的途径,Ferezou等选择了小鼠的腮须运动系统作为研究对象。他们利用电压敏感染料在小鼠的大脑皮层,通过类似柱形的空间分辨率和毫秒的时间精度的对大脑皮层感觉运动的膜电压的动态变化直接成像。研究表明:单个腮须短促的位置偏移就会引起高度分布式极化皮质感觉的反应,由此开始了在初级体感桶型大脑皮质及随后的兴奋腮须运动皮层。腮须运动以及引起该运动的感觉能够动态地调节感觉信息到运动皮层的传递过程。大脑皮质感觉运动的过程可能大大有助于人们对触觉的认知。(科学网)
原始出处:
Neuron, Vol 56, 907-923, 06 December 2007
Spatiotemporal Dynamics of Cortical Sensorimotor Integration in Behaving Mice
Isabelle Ferezou,1,3 Florent Haiss,2 Luc J. Gentet,1 Rachel Aronoff,1 Bruno Weber,2 and Carl C.H. Petersen1,
1 Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland
2 Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
Corresponding author
Carl C.H. Petersen
carl.petersen@epfl.ch
Summary
Tactile information is actively acquired and processed in the brain through concerted interactions between movement and sensation. Somatosensory input is often the result of self-generated movement during the active touch of objects, and conversely, sensory information is used to refine motor control. There must therefore be important interactions between sensory and motor pathways, which we chose to investigate in the mouse whisker sensorimotor system. Voltage-sensitive dye was applied to the neocortex of mice to directly image the membrane potential dynamics of sensorimotor cortex with subcolumnar spatial resolution and millisecond temporal precision. Single brief whisker deflections evoked highly distributed depolarizing cortical sensory responses, which began in the primary somatosensory barrel cortex and subsequently excited the whisker motor cortex. The spread of sensory information to motor cortex was dynamically regulated by behavior and correlated with the generation of sensory-evoked whisker movement. Sensory processing in motor cortex may therefore contribute significantly to active tactile sensory perception.
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