11月14日在线发表于《神经病学年鉴》（Ann Neurol）上的美国一项研究"Solvent exposures and parkinson disease risk in twins"显示，暴露于特定溶剂可能增加帕金森病（PD）患病风险。
研究纳入99对PD状况不一致的双胞胎，采用问卷评估终生职业和爱好。结果为，既往暴露于三氯乙烯（TCE）与PD风险显著升高相关[比值比（OR）为6.1；P=0.034]，暴露于四氯乙烯（PERC）和四氯化碳（CCl4）倾向于具显著相关性（OR分别为10.5和2.3；P分别为0.053和0.088）。暴露持续时间和累积终生暴露的相关估计结果与之相似。（生物谷Bioon.com）
doi:10.1002/ana.22629
PMC:
PMID:
Solvent exposures and parkinson disease risk in twins
Samuel M. Goldman MD, MPH1,*, Patricia J. Quinlan MPH, CIH2, G. Webster Ross MD3, Connie Marras MD, PhD4, Cheryl Meng MS1, Grace S. Bhudhikanok PhD1, Kathleen Comyns MPH1, Monica Korell MPH1, et al.
Objective:Several case reports have linked solvent exposure to Parkinson disease (PD), but few studies have assessed associations with specific agents using an analytic epidemiologic design. We tested the hypothesis that exposure to specific solvents is associated with PD risk using a discordant twin pair design.
Methods:Ninety-nine twin pairs discordant for PD ascertained from the National Academy of Sciences/National Research Council World War II Veteran Twins Cohort were interviewed regarding lifetime occupations and hobbies using detailed job task–specific questionnaires. Exposures to 6 specific solvents selected a priori were estimated by expert raters unaware of case status.
Results:Ever exposure to trichloroethylene (TCE) was associated with significantly increased risk of PD (odds ratio [OR], 6.1; 95% confidence interval [CI] 1.2–33; p = 0.034), and exposure to perchloroethylene (PERC) and carbon tetrachloride (CCl4) tended toward significance (respectively: OR, 10.5; 95% CI, 0.97–113; p = 0.053; OR, 2.3; 95% CI, 0.9–6.1; p = 0.088). Results were similar for estimates of exposure duration and cumulative lifetime exposure.
Interpretation:Exposure to specific solvents may increase risk of PD. TCE is the most common organic contaminant in groundwater, and PERC and CCl4 are also ubiquitous in the environment. Our findings require replication in other populations with well-characterized exposures, but the potential public health implications are substantial.
