目前,一项发表在Psychiatry Res杂志上的研究"An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample"指出,与出生体重正常的新生儿相比,出生体重较高(HBW)的新生儿发展为精神分裂症的风险增加2倍。
本项研究发现与低体重与精神分裂症相关这一结果相矛盾,但与先前的4项研究结果相一致。
Asko Wegelius(National Institute for Health and Welfare, Helsinki, Finland)和他的同事们说道:“本研究发现与先前的研究结果相一致,即HBW是发展为精神分裂症的一种可能的危险因素,这提示我们可能需要对与精神分裂症相关的低体重儿和高体重儿进行评估。”
本研究纳入来自315个Finnish家庭的1,051例儿童, 这些家庭中至少有一例儿童被诊断为精神分裂症,对受试者的出生体重数据进行评估。同时,通过从药物报销登记处获取相关信息和问诊的方式,对罹患II型糖尿病的母亲和其子女罹患精神分裂症风险之间的相关性进行探讨。
生存曲线分析显示,出生体重2500-2999g和3000-4000g的风险轨迹相似。出生体重>4000g与发展为精神分裂症相关。出生体重<2500g的风险轨迹介于精神分裂症和主要精神障碍组的高体重和中间体重风险轨迹之间。
对出生体重、性别、产妇和父亲的精神障碍史进行校正后,HBW新生儿发展为精神分裂症的风险增加1.68倍。HBW与主要的精神障碍之间无相关性。此外低体重(LBW)与主要的精神障碍和精神分裂症之间无相关性。
罹患糖尿病的母亲,其子女的出生体重与无糖尿病母亲的子女相似。罹患糖尿病的母亲与高体重(HBW)新生儿之间无相关性。然而,母亲罹患糖尿病与其子女发展为精神分裂症和主要精神障碍高度相关,其风险率比值(HRR)分别为1.66和1.55。
本项研究的作者们指出,HBW或母亲罹患糖尿病增加精神分裂症风险,而非增加主要精神障碍易感性风险,这提示精神分裂症和非精神分裂性-精神障碍之间的潜在病因学机制具有部分独立性。(生物谷Bioon.com)
doi:10.1016/j.psychres.2011.05.035
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An association between high birth weight and schizophrenia in a Finnish schizophrenia family study sample
Asko Wegelius,Annamari Tuulio-Henriksson,Maiju Pankakoski,Jari Haukka,Ulriika Lehto,Tiina Paunio,Jouko L.nnqvist,Jaana Suvisaari
Longitudinal cohort studies have implicated an association between both low and high birth weight and schizophrenia. It has been suggested that schizophrenia associated genes could augment an individual's susceptibility to adverse prenatal and perinatal environmental events. We investigated the association between birth weight and schizophrenia in a large Finnish schizophrenia family study sample. We utilized the birth weight data of 1051 offspring from 315 Finnish families with at least one offspring with a diagnosis of schizophrenia. We used a multivariate COX frailty model to analyze the effect of birth weight on the risk of developing schizophrenia within the families. Using information from the Medication Reimbursement Register and patient interviews, we further investigated the association of maternal type 2 diabetes and schizophrenia risk among offspring. High birth weight (>4000g) was associated with a 1.68-fold increase in schizophrenia susceptibility. Maternal diabetes at the time of data collection, a proxy for gestational diabetes, was associated with a 1.66-fold increase in the risk of developing schizophrenia among offspring. Our results corroborate recent findings showing an association between high birth weight and schizophrenia. Our results also point to a potential birth-weight independent association between maternal type 2 diabetes and schizophrenia among offspring.