根据Neurolog最新的一项研究，每天饮酒3次或更多的重度饮酒者患脑出血的风险增加，他们发病的年龄比那些不饮酒的患者要早。
法国里尔大学的研究人员报告，一般来说，重度饮酒者患脑出血相比其他常见的缺血性卒中，有更可怕的预后——比不喝酒的患者发病年龄提前14年。
重度酗酒者最有可能在脑深部发生卒中，神经病学博士Charlotte Cordonnier和他的同事指出。60岁以下的患者随访2年后，死亡的可能性比其他患者要高。对于没有显著的既往病史的年轻人，每天喝大量的酒，有助于更严重的卒中。
为了进行分析，Cordonnier和她的团队随访2004年11月至2009年4月在里尔大学附属医院寻求脑血管治疗的患者。该团队采访了患者以及患者的亲属，关于他们的饮酒习惯。
参与者中，1/4患者是重度饮酒者，他们卒中的发病年龄中值是60，不饮酒的患者患卒中的年龄是74岁。这两组有类似的并发症发生率，以及住院时间。
重度饮酒在以往已被确定为此类卒中的一个危险因素，但研究没有梳理出遭受不同部位的脑出血患者之间的差异。
“在这项研究中，我们选择的方法突出一个事实，重度饮酒对不同部位的脑出血影响不同”，研究人员提到。（生物谷Bioon.com）
doi:10.1212/WNL.0b013e3182698d00
PMC:
PMID:
Heavy alcohol intake and intracerebral hemorrhage: Characteristics and effect on outcome.
Casolla B, Dequatre-Ponchelle N, Rossi C, Hénon H, Leys D, Cordonnier C.
Abstract
OBJECTIVES: To identify associated factors and influence on long-term outcome of heavy alcohol intake in a large prospective cohort of consecutive patients with a spontaneous intracerebral hemorrhage (ICH).
METHODS: Between November 2004 and March 2009, we prospectively recruited 562 consecutive adults with a spontaneous ICH. We excluded patients without information on drinking habit (n = 22). Heavy alcohol intake was defined as a regular consumption of more than 300 g alcohol/week. We performed bivariate and multivariate analyses (logistic regression) based on demographic and radiologic models. Survival analyses were performed using Kaplan-Meier statistics.
RESULTS: Among 540 patients with ICH, 137 (25) were heavy alcohol drinkers (median age 60 vs 74 years in nonabusers; p < 0.0001). In the multivariate demographic model, heavy alcohol drinkers were less likely to be older (odds ratio [OR] 0.97 per 1-year increase, 95% confidence interval [CI] 0.95-0.98) and to have a history of ischemic heart disease (OR 0.34, 95% CI 0.15-0.77) and more likely to be smokers (OR 3.96, 95% CI 2.43-6.46). In the radiologic model, independent factors were nonlobar location of ICH (OR 1.71, 95% CI 1.05-2.77) and less severe leukoaraiosis (OR 0.76 per 1-step increase, 95%CI 0.62-0.73). Platelet counts and prothrombin ratio were significantly lower among heavy alcohol drinkers (respectively, p = 0.01 and p = 0.017). Heavy alcohol intake was predictive of 2 years mortality only among patients younger than 60 years with nonlobar ICH (hazard ratio 1.96, 95% CI 1.06-3.63).
CONCLUSION: Heavy alcohol intake is associated with the occurrence of ICH at a young age. However, the underlying vasculopathy remains unexplored in these patients. Indirect markers suggest small-vessel disease at an early stage that might be enhanced by moderate hemostatic disorders.
