2012年12月3日 讯 /生物谷BIOON/ --近日，刊登在国际杂志the Journals of Gerontology Series A：Biological Sciences and Medical Sciences上的两项研究成果揭示了，维生素D或许是改善妇女认知能力的重要成分。
饮食中较高水平维生素D的摄入和低风险的阿尔兹海默症风险直接相关，来自明尼阿波利斯（Minneapolis）退伍军人医疗中心的研究者指出，在老年妇女中，低水平的维生素D和高风险的认知损伤、认知功能下降直接相关。
研究者Slinin对6257名社区长期居住的老年妇女进行研究揭示了，低水平的维生素D（每毫升血液中少于10毫微克）和高风险的认知功能损伤直接相关，每毫升血液中维生素D少于20毫微克的老年妇女，其患认知功能下降的风险明显增加。
另外研究者Annweieler度498名社区常住妇女进行了研究，发现患有阿尔兹海默症的患者，其摄入的维生素D水平较低，平均每周摄入50.3微克，而患别的痴呆的患者其每周摄入63.6微克，没有任何痴呆的个体其每周维生素D的摄入为59.0微克。
这些研究成果揭示了，无论是男性还是女性，如果日常维生素D摄入不够，那么其患运动性限制疾病或者认知残疾的风险将会增加。（生物谷Bioon.com）
doi:10.1093/gerona/gls107
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Higher Vitamin D Dietary Intake Is Associated With Lower Risk of Alzheimer’s Disease: A 7-Year Follow-up
Cédric Annweiler1, Yves Rolland2, Anne M Schott3, Hubert Blain4, Bruno Vellas2, François R. Herrmann5 and Olivier Beauchet1
Background. Hypovitaminosis D is associated with cognitive decline among older adults. The relationship between vitamin D intakes and cognitive decline is not well understood. Our objective was to determine whether the dietary intake of vitamin D was an independent predictor of the onset of dementia within 7 years among women aged 75 years and older. Methods. Four hundred and ninety-eight community-dwelling women (mean, 79.8 ± 3.8 years) free of vitamin D supplements from the EPIDemiology of OSteoporosis Toulouse cohort study were divided into three groups according to the onset of dementia within 7 years (ie, no dementia, Alzheimer’s disease [AD], or other dementias). Baseline vitamin D dietary intakes were estimated from self-administered food frequency questionnaire. Age, body mass index, initial cognitive performance, education level, physical activity, sun exposure, disability, number of chronic diseases, hypertension, depression, use of psychoactive drugs, and baseline season were considered as potential confounders. Results. Women who developed AD (n = 70) had lower baseline vitamin D intakes (mean, 50.3 ± 19.3 μg/wk) than nondemented (n = 361; mean intake = 59.0 ± 29.9 μg/wk, p = .027) or those who developed other dementias (n = 67; mean intake = 63.6 ± 38.1 μg/wk, p = .010). There was no difference between other dementias and no dementia (p = .247). Baseline vitamin D dietary intakes were associated with the onset of AD (adjusted odds ratio = 0.99 [95% confidence interval = 0.98–0.99], p = .041) but not with other dementias (p = .071). Being in the highest quintile of vitamin D dietary intakes was associated with a lower risk of AD compared with the lower 4 quintiles combined (adjusted odds ratio = 0.23 [95% confidence interval = 0.08–0.67], p = .007). Conclusions. Higher vitamin D dietary intake was associated with a lower risk of developing AD among older women.
doi:10.1093/gerona/gls136
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Low 25-Hydroxyvitamin D Predicts the Onset of Mobility Limitation and Disability in Community-Dwelling Older Adults: The Health ABC Study
Denise K. Houston1, Rebecca H. Neiberg2, Janet A. Tooze2, Dorothy B. Hausman3, Mary Ann Johnson3, Jane A. Cauley4, Doug C. Bauer5, M. Kyla Shea1, Gary G. Schwartz6, Jeff D. Williamson1, Tamara B. Harris7 and Stephen B Kritchevsky1 for the Health ABC StudyP>
Background. Although low 25-hydroxyvitamin D (25(OH)D) is prevalent among older adults and is associated with poor physical function, longitudinal studies examining vitamin D status and physical function are lacking. We examined the association between 25(OH)D, parathyroid hormone (PTH), and the onset of mobility limitation and disability over 6 years of follow-up in community-dwelling, initially well-functioning older adults participating in the Health, Aging and Body Composition study (n = 2,099). Methods. Serum 25(OH)D and PTH were measured at the 12-month follow-up visit (1998–1999). Mobility limitation and disability (any/severe difficulty walking 1/4 mile or climbing 10 steps) was assessed semiannually over 6 years of follow-up. The association between 25(OH)D, PTH, and mobility limitation and disability was examined using Cox proportional hazard regression models adjusted for demographics, season, behavioral characteristics, and chronic conditions. Results. At baseline, 28.9% of the participants had 25(OH)D <50 nmol/L and 36.1% had 25(OH)D of 50 to <75 nmol/L. Participants with 25(OH)D <50 and 50 to <75 nmol/L were at greater risk of developing mobility limitation (HR (95% CI): 1.29 (1.04–1.61) and 1.27 (1.05–1.53), respectively) and mobility disability (HR (95% CI): 1.93 (1.32–2.81) and 1.30 (0.92–1.83), respectively) over 6 years of follow-up compared with participants with 25(OH)D ≥75 nmol/L. Elevated PTH, however, was not significantly associated with developing mobility limitation or disability. Conclusions. Low 25(OH)D was associated with an increased risk of mobility limitation and disability in community-dwelling, initially well-functioning black and white older adults. Prevention or treatment of low 25(OH)D may provide a pathway for reducing the burden of mobility disability in older adults.
