脊神经后根切断后导致反射性阴茎勃起功能丧失，影响痉挛性膀胱患者的生活质量。一项关于“Selective control by posterior spinal nerve roots of micturition and erection in rats ”的研究显示，SD大鼠L6、S1脊神经后根不同神经小束对膀胱逼尿肌、尿道外括约肌和阴茎海绵体的传导效能存在差别，通过电刺激可以区别不同的神经小束。作者认为，高选择切断支配尿道外括约肌的骶前根小束可以解除括约肌痉挛，从而达到低压排尿及提高膀胱协调性的目的；通过高选择切断传导逼尿肌脊神经后根可以缓解膀胱痉挛，达到扩大膀胱容量同时保留勃起功能的目的。该研究可为临床高选择性脊神经后根小束切断治疗痉挛性膀胱提供理论依据。相关研究成果发表在《中国神经再生研究（英文版）》杂志于2012年12 月35 期出版的杂志上。(生物谷Bioon.com)
doi:10.3969/j.issn.1673-5374.2012.35.001
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Selective control by posterior spinal nerve roots of micturition and erection in rats
Wenting Wang, Mouwang Zhou, Genying Zhu, Tao Li, Nan Liu
The posterior rootlets in L6 and S1 spinal cord of adult male Sprague-Dawley rats underwent electrostimulation. The bladder pressure, urethral perfusion pressure and intracavernous pressure were recorded. When some posterior rootlets of L6 and S1 were electrostimulated, the intracavernous pressure peaked rapidly, but the bladder pressure and the urethral perfusion pressure curve did not show great change. When other rootlets were stimulated, the bladder pressure changed greatly, but the urethral perfusion pressure and the intracavernous pressure did not show great change. When different rootlets were stimulated, the urethral perfusion pressure changed maximally, but there were no great changes in bladder pressure or intracavernous pressure. Furthermore, stimulation of some rootlets produced simultaneous changes in two or three different pressure measures mentioned above. The results demonstrate that regulation by L6 and S1 posterior rootlets of the rat bladder detrusor, external urethral sphincter and penis cavernous body are significantly distinct. Different rootlets can be distinguished by electrostimulation.
