尽管在过去的10年里，产科和新生儿科的治疗技术取得了重要进展，但围产期缺氧缺血仍是新生儿死亡的重要原因之一。
缺氧缺血性脑病常引起运动障碍性脑性瘫痪，由于缺氧缺血性脑损伤通常是不可预期的，所以损伤后的干预显得尤为重要。
近年来对此问题的研究主要集中在应用神经保护剂治疗围产期缺氧缺血性脑病效果的评价方面。来自西班牙的Idoia Lara Celador所在团队于2013年3月第8期《中国神经再生研究（英文版）》Neural Regen Res杂志发表的一篇文章，“Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic- ischemic brain injury”综述了缺氧缺血性脑病的病理损害，以及各种神经保护手段对缺氧缺血性脑病的治疗效果，重点分析了内源性大麻素系统作为天然的神经保护系统，在缺氧缺血性脑损伤防治中所发挥的重要作用。（生物谷Bioon.com）
doi:10.3969/j.issn.1673-5374.2013.08.008
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Using the endocannabinoid system as a neuroprotective strategy in perinatal hypoxic- ischemic brain injury
Lara-Celador, I.1, Goñi-de-Cerio, F.2, Antonia Alvarez1, Enrique Hilario1
One of the most important causes of brain injury in the neonatal period is a perinatal hypoxic- ischemic event. This devastating condition can lead to long-term neurological deficits or even death. After hypoxic-ischemic brain injury, a variety of specific cellular mechanisms are set in motion, triggering cell damage and finally producing cell death. Effective therapeutic treatments against this phenomenon are still unavailable because of complex molecular mechanisms underlying hypoxic-ischemic brain injury. After a thorough understanding of the mechanism underlying neural plasticity following hypoxic-ischemic brain injury, various neuroprotective therapies have been developed for alleviating brain injury and improving long-term outcomes. Among them, the endocannabinoid system emerges as a natural system of neuroprotection. The endocannabinoid system modulates a wide range of physiological processes in mammals and has demonstrated neuroprotective effects in different paradigms of acute brain injury, acting as a natural neuroprotectant. The aim of this review is to study the use of different therapies to induce long-term therapeutic effects after hypoxic-ischemic brain injury, and analyze the important role of the endocannabinoid system as a new neuroprotective strategy against perinatal hypoxic-ischemic brain injury.
