化疗是肿瘤的主要治疗手段之一，在取得疗效的同时，还发现这种治疗方法会引起一系列神经系统副作用，如血管并发症、癫痫、情绪异常、认知功能障碍和周围神经病变。化疗引起背根神经节和背角神经元离子通道变化，引起继发性损伤神经病理痛。尽管现在已开发出许多化疗保护剂，但其作用效果仍不理想。化疗药物可引起海马神经发生和神经可塑性发生变化。发表于2013年6月第17期《中国神经再生研究（英文版）》杂志的“Neurotoxicity of cancer chemotherapy”聚集于化疗药物引发的神经退行性变和与记忆关系最为密切的海马功能障碍的体内和体外研究进展。这将为进一步研究化疗药物引发的神经系统副作用提供帮助，并为新型化疗药物的研发提供线索。（生物谷Bioon.com）
生物谷推荐英文摘要：
Neural Regeneration Research doi: 10.3969/j.issn.1673-5374.2013.17.009
Neurotoxicity of cancer chemotherapy
Miyoung Yang, Changjong Moon
There is accumulating clinical evidence that chemotherapeutic agents induce neurological side effects, including memory deficits and mood disorders, in cancer patients who have undergone chemotherapeutic treatments. This review focuses on chemotherapy-induced neurodegeneration and hippocampal dysfunctions and related mechanisms as measured by in vivo and in vitro approaches. These investigations are helpful in determining how best to further explore the causal mechanisms of chemotherapy-induced neurological side effects and in providing direction for the future development of novel optimized chemotherapeutic agents.
