生物谷报道：转录因子Kruppel-like transcription factors （KLF2）长期被认为在控制成熟T细胞的存活和静止中扮演一个关键角色，因为缺乏KLF2的T细胞会在胸腺中形成，但不能进入周围淋巴器官。
本周出版的Nature上一项新的研究工作对这种表现型提出了另一种解释，这种解释与KLF2作为胸腺细胞和T细胞迁移的一个调控因子这样一个完全不同的功能是一致的。 KLF（Krüppel类转录因子）家族的蛋白参与脊椎动物发育的很多方面，并且与若干疾病状态有关。KLF2这一新发现的功能与不同细胞类型的终端分异所必需的其他一些KLF是相似的。同时，编辑对此文章进行了相关的评论。
The transcription factor KLF2 has long been thought to play a critical role in controlling survival and quiescence of mature T cells, since KLF2-deficient T cells develop in the thymus but fail to populate peripheral lymph organs. A new study offers an alternative explanation for this phenotype, consistent with an entirely different function for KLF2 as a regulator of thymocyte and T-cell migration. Proteins of the KLF (Krüppel-like transcription factor) family are involved in many aspects of vertebrate development and are implicated in a number of disease states. This newly discovered role for KLF2 is similar to some other KLFs that are essential for terminal differentiation of various cell types.
原始出处：
Letter: Kruppel-like factor 2 regulates thymocyte and T-cell migration
Corey M. Carlson, Bart T. Endrizzi, Jinghai Wu, Xiaojie Ding, Michael A. Weinreich, Elizabeth R. Walsh, Maqsood A. Wani, Jerry B. Lingrel, Kristin A. Hogquist and Stephen C. Jameson
doi:10.1038/nature04882
First paragraph | Full Text | PDF (482K) | Supplementary information
