辛辛那提大学的研究人员证实了婴儿暴露于室内某些霉菌的组成,有助于建立更强的免疫系统,并保护他们免于未来发生过敏。
研究人员发现暴露于高浓度室内霉菌成分:葡聚糖的婴儿,相较于暴露低浓度的婴儿,发生气喘的可能性低了三倍。科学家相信霉菌是造成成人呼吸症状的微小分子,在地上爬行的婴儿经常暴露于这些分子中。
这项研究的主要作者和环境健康科学家Yulia Iossifova表示,暴露于高浓度的霉菌组成分子中,可避免婴儿发生过敏。
只有当暴露于高浓度的微生物时,免疫系统的防护机制才会发挥效果。因此太过干净的环境中,没有足够的微生物组成分引起免疫系统反应。这项研究结果发表于5月号的Allergy中。这项流行病学研究建议,及早暴露于室内霉菌葡聚糖,对于人类免疫系统具有正面影响。
(姜欣慧译) (资料来源 : biocompare)
英文原文链接:
http://news.biocompare.com/newsstory.asp?id=180704
原始出处:
Allergy,Volume 62 Issue 5 Page 504 - May 2007
To cite this article: Y. Y. Iossifova, T. Reponen, D. I. Bernstein, L. Levin, H. Kalra, P. Campo, M. Villareal, J. Lockey, G. K. K. Hershey, G. LeMasters (2007)
House dust (1-3)-β-d-glucan and wheezing in infants
Allergy 62 (5), 504–513.
doi:10.1111/j.1398-9995.2007.01340.x
House dust (1–3)-β-d-glucan and wheezing in infants
Y. Y. Iossifova11Department of Environmental Health, University of Cincinnati, T. Reponen11Department of Environmental Health, University of Cincinnati, D. I. Bernstein22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, L. Levin11Department of Environmental Health, University of Cincinnati, H. Kalra22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, P. Campo22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, M. Villareal22Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati, J. Lockey11Department of Environmental Health, University of Cincinnati, G. K. K. Hershey33Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, G. LeMasters11Department of Environmental Health, University of Cincinnati
1Department of Environmental Health, University of Cincinnati; 2Division of Allergy-Immunology, Department of Internal Medicine, University of Cincinnati; 3Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA
Abstract
Background: (1–3)-β-d-glucan is a fungal cell wall component, suspected to cause respiratory symptoms in adults. However, very little is known on the possible health effects of (1–3)-β-d-glucan during infancy. We examined the association between (1–3)-β-d-glucan exposure and the prevalence of allergen sensitization and wheezing during the first year of life in a birth cohort of 574 infants born to atopic parents. Endotoxin exposure was included as a possible confounder.
Methods: (1–3)-β-d-glucan and endotoxin exposures were measured in settled dust collected from infants’ primary activity rooms. The primary outcomes at approximately age one included parental reports of recurrent wheezing and allergen sensitization evaluated by skin prick testing to a panel of 15 aeroallergens as well as milk and egg white.
Results: Exposure to high (1–3)-β-d-glucan concentration (within fourth quartile) was associated with reduced likelihood of both recurrent wheezing [adjusted OR (aOR) = 0.39, 95% CI = 0.16–0.93] and recurrent wheezing combined with allergen sensitization (aOR = 0.13, 95% CI = 0.03–0.61). Similar trends were found between (1–3)-β-d-glucan concentrations and allergen sensitization (aOR = 0.57, 95% CI = 0.30–1.10). In contrast, recurrent wheezing with or without allergen sensitization was positively associated with low (1–3)-β-d-glucan exposure within the first quartile (aOR = 3.04, 95% CI = 1.25–7.38; aOR = 4.89, 95% CI = 1.02–23.57). There were no significant associations between endotoxin exposure and the studied health outcomes.
Conclusions: This is the first study to report that indoor exposure to high levels of (1–3)-β-d-glucan (concentration >60 μg/g) is associated with decreased risk for recurrent wheezing among infants born to atopic parents. This effect was more pronounced in the subgroup of allergen-sensitized infants.