生物谷报道：研究人员在9月在线出版的《自然—免疫学》期刊上报告：血液干细胞在神经细胞信号的作用下会被激活。
Tsvee Lapidot和同事在实验中发现，骨髓干细胞表达出了多巴胺受体。在压力状态下释放的神经传递素能诱发血细胞分化，并从保护它们的骨髓环境中迁移出来。用多巴胺或其他神经传递素对小鼠进行治疗，会导致小鼠骨髓和血液循环中的干细胞数量的增加。同样地，刺激人体骨髓细胞中的神经传递素也能增加它们移植到“人源化鼠”中的可能性，这种“人源化鼠”的免疫系统用人体细胞进行了重组。
对于需要骨髓移植的治疗来说，新发现可用于提高治疗效率的研究。（科学时报）
原始出处:
Nature Immunology
Published online: 9 September 2007 | doi:10.1038/ni1509
Catecholaminergic neurotransmitters regulate migration and repopulation of immature human CD34+ cells through Wnt signaling
Asaf Spiegel1, Shoham Shivtiel1, Alexander Kalinkovich1, Aya Ludin1, Neta Netzer1, Polina Goichberg1, Yaara Azaria1, Igor Resnick2, Izhar Hardan3, Herzel Ben-Hur4, Arnon Nagler3, Menachem Rubinstein5 & Tsvee Lapidot1
Abstract
Catecholamines are important regulators of homeostasis, yet their functions in hematopoiesis are poorly understood. Here we report that immature human CD34+ cells dynamically expressed dopamine and 2-adrenergic receptors, with higher expression in the primitive CD34+CD38lo population. The myeloid cytokines G-CSF and GM-CSF upregulated neuronal receptor expression on immature CD34+ cells. Treatment with neurotransmitters increased the motility, proliferation and colony formation of human progenitor cells, correlating with increased polarity, expression of the metalloproteinase MT1-MMP and activity of the metalloproteinase MMP-2. Treatment with catecholamines enhanced human CD34+ cell engraftment of NOD-SCID mice through Wnt signaling activation and increased cell mobilization and bone marrow Sca-1+c-Kit+Lin- cell numbers. Our results identify new functions for neurotransmitters and myeloid cytokines in the direct regulation of human and mouse progenitor cell migration and development.
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah-Hebrew University Medical Center, Jerusalem 91120, Israel.
Department of Hematology & Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
Assaf Haroffe Medical Center, Tsrifin 70300, Israel.
Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel.
Correspondence to: Tsvee Lapidot1 e-mail: tsvee.lapidot@weizmann.ac.il
