8月中旬，来自中科院上海生化所干细胞生物学重点实验室，上海交通大学医学院，瑞金医院等处的研究人员Cell Host & Microbe上发表了题为“An Essential Role for RIG-I in Toll-like Receptor-Stimulated Phagocytosis”的研究论文。
这篇文章发现了RIG-I在Toll样受体TLR刺激的吞噬作用中扮演的一个出乎意料的作用，即RIG-I具有广泛的调控作用，不仅是在抗病毒应答过程中，而且在抗细菌应答中也起着重要的作用。
这一研究成果对于进一步了解Toll样受体刺激的吞噬作用，以及RIG-I在各信号传导过程中的作用，具有重要的参考意义。（生物谷Bioon.com）
生物谷推荐原始出处：
Cell Host & Microbe, Volume 6, Issue 2, 150-161, 20 August 2009 doi:10.1016/j.chom.2009.06.008
An Essential Role for RIG-I in Toll-like Receptor-Stimulated Phagocytosis
Ling Kong1,4,6,Lei Sun1,4,6,Hongxin Zhang2,Qin Liu1,Ye Liu1,Linhua Qin1,Guojun Shi1,4,Jun-Hao Hu1,4,Ajing Xu1,Yue-Ping Sun2,Dangsheng Li5,Yu-Fang Shi1,Jing-Wu Zang1,Jiang Zhu3,Zhu Chen3,Zhu-Gang Wang2,3,,andBao-Xue Ge1,,
1 The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai JiaoTong University School of Medicine, Shanghai 200025, China
2 Laboratory of Genetic Engineering, Department of Medical Genetics, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China
3 State Key Laboratory for Medical Genomics and Shanghai Institute of Hematology, RuiJin Hospital, Shanghai 200025, China
4 Graduate School of Chinese Academy of Sciences, Beijing 100039, China
5 Shanghai Information Center for Life Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Retinoic acid-inducible gene-I (RIG-I) plays an important role in antiviral response by recognizing double-stranded RNA. Here we demonstrate an unanticipated role of RIG-I in Toll-like receptor (TLR)-stimulated phagocytosis. Stimulation with lipopolysaccharide (LPS), a ligand of TLR4, induced the expression of RIG-I in macrophages. Depletion of RIG-I by RNAi or gene targeting inhibited the LPS-induced phagocytosis of bacteria. Cellular processes involved in phagocytosis, such as small GTPase Cdc42/Rac1 activation, actin polymerization, and actin-regulator Arp2/3 recruitment, were also impaired in RIG-I-deficient macrophages activated by LPS. Moreover, RIG-I/ mice were found to be more susceptible to infection with Escherichia coli as compared to wild-type mice. Thus, the regulatory functions of RIG-I are strikingly broad, including a role not only in antiviral responses but in antibacterial responses as well.
