丹麦一项研究显示，银屑病与中风和心房颤动有关，年纪越轻、银屑病症状越严重的患者，患中风和心房颤动几率越大。
显关联
丹麦哥本哈根大学根措夫特医院心脏病专家奥勒·阿勒霍夫与同事分析丹麦约450万青少年与成年人1997年至2006年间的数据。这些人中，约3.7万人有中度银屑病，2793人症状严重。
分析结果显示，年龄50岁以下患有中度银屑病的人，心房颤动几率比普通人多50%，缺血性中风几率多97%。银屑病症状严重的人，心房颤动和缺血性中风的几率比普通人多198%和180%。
50岁以上银屑病患者患心房颤动和中风的几率大大降低。
心房颤动简称房颤，是最常见的心率失常之一，可能引起心力衰竭和动脉栓塞等严重并发症。缺血性中风是指脑血栓引起的脑梗塞和脑动脉堵塞，通常会引发偏瘫和意识障碍。
增风险
英国广播公司28日引述研究人员的话报道：“心房颤动和缺血性中风的危险在那些年轻且银屑病症状严重的人中最高。这一研究结果进一步证明，银屑病患者患心血管疾病的风险更大。”
近年来，一系列研究相继证明银屑病与心脏和血管问题存在关联。阿勒霍夫说，在人们的认知中，“银屑病从一种单纯影响外貌的疾病成为一种系统疾病，是增加心血管疾病的风险因素”。
中风协会研究员沙尔林·艾哈迈德说：“先前研究已经表明，银屑病会增加心脏病风险，这一研究显示，它还会增加心房颤动和中风风险。”
研究结果由最新一期《欧洲心脏期刊》发表。不过艾哈迈德说，研究结果并不意味着银屑病一定引发房颤和中风。
重健康
银屑病是一种常见慢性皮肤病，特征是在红斑上反复出现多层银白色干燥鳞屑，又被称为牛皮癣，是一种免疫系统疾病。
正常情况下，人体皮肤细胞每三周至四周更新一次，但是银屑病人的免疫系统攻击健康细胞，导致皮肤细胞更新的速度加快到两天至六天一次，这样，老旧细胞来不及从皮肤上脱落，导致红肿和多层干屑出现。
研究人员说，免疫系统攻击健康细胞会引发炎症，这种炎症可能与中风和心脏问题有关。
艾哈迈德建议银屑病人定期检查心脏，改善生活方式，比如戒烟、多做运动，从而降低罹患心脏病风险。(生物谷 Bioon.com)
doi:10.1093/eurheartj/ehr285
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Psoriasis and risk of atrial fibrillation and ischaemic stroke: a Danish Nationwide Cohort Study
Ole Ahlehoff, Gunnar H. Gislason, Casper H. J rgensen, Jesper Lindhardsen, Mette Charlot, Jonas B. Olesen, Steen Z. Abildstr m, Lone Skov, Christian Torp-Pedersen and Peter Riis Hansen
Aims Psoriasis is a chronic inflammatory disease and inflammation contributes to the pathogenesis of atrial fibrillation (AF) and ischaemic stroke. We therefore investigated the risk of these endpoints in patients with psoriasis. Methods and results Cohort study of the entire Danish population followed from 1997 to 2006 by individual-level-linkage of nationwide prospectively recorded registers. Multivariable Poisson's regression and sensitivity analyses were used to assess the psoriasis-related risk of AF and ischaemic stroke. A total of 36 765 patients with mild psoriasis and 2793 with severe psoriasis were compared with 4 478 926 individuals, i.e. the reference population. In patients with mild psoriasis, the adjusted rate ratios (RRs) for AF were 1.50 (1.21–1.86) and 1.16 (1.08–1.24) in patients aged <50 and ≥50 years, respectively. Patients with severe psoriasis had a higher risk of AF with RRs 2.98 (1.80–4.92) in patients aged <50 years and 1.29 (1.01–1.65) in patients aged ≥50 years. Patients with psoriasis also demonstrated a disease severity-dependent increased risk of ischaemic stroke, i.e. RRs 1.97 (1.66–2.34) and 2.80 (1.81–4.34) in patients aged <50 years with mild and severe psoriasis, and RRs 1.13 (1.04–1.21) and 1.34 (1.04–1.71) in patients aged ≥50 years with mild and severe psoriasis, respectively. A range of sensitivity analyses yielded comparable results. Conclusion Psoriasis is associated with increased risk of AF and ischaemic stroke. These novel results add to a growing body of evidence, suggesting that patients with psoriasis could be considered at increased cardiovascular risk.
