生物工程学报 25 June 2009, 25(6):909～913
基于微生物的可控生物制造
史续典, 王刚, 王大明, 余龙江, 杨光
华中科技大学生命科学与技术学院 国家纳米药物工程技术中心, 武汉 430074
摘 要: 微生物种类丰富, 尺寸涵盖纳米与微米级, 是天然的可用于纳米、微米及多层次跨尺度加工的"基本单元"。目前的生物制造方法大多不适用于微生物活细胞, 无法发挥其整体的生物学功能及优势。本研究探索并建立了微流控和磁控的可用于微生物活体的微纳米生物制造新方法, 定位操纵和有序排列微生物活体。以微生物为微纳米机器人, 诱发其特有的生物学功能, 进行受控自组装等生物制造过程, 由此有望设计和创制一系列新型特殊功能材料和器件。
关键词: 微纳生物制造, 微流控技术, 磁控微生物, 细菌纤维素, 仿生矿化
Controllable bio-fabrication based on microbes
Xudian Shi, Gang Wang, Daming Wang, Longjiang Yu, and Guang Yang
National Engineering Research Center for Nano-Medicine, College of Life Science & Technology, Huazhong University of Science & Technology Wuhan 430074, China
Abstract: Microorganisms in nature have rich variety, whose sizes are from nano scale to micro scale. Therefore, microbes can be used as natural "building blocks" in nano/micro multi-level fabrication processes. At present, most of the bio-manufacturing methods do not apply to direct control of living microbes. Their microbiological global functions and superiorities are not available. In this paper, two novel nano/micro bio-fabrication approaches, micro-fluidic control method and magnetic control method have been established. The living microbes could be manipulated to form micro-scaled patterns or to move orientedly. By these approaches, living microbes are taken as nano/micro robots. We could employ their specific biological functions and regulate their controllable self-assembly, which is expected to design and create a series of new special functional materials and devices.
Keywords: nano/micro bio-fabrication, micro-fluidic technique, magnetic controllable microbes, bacterial cellulose, biomimetic mineralization
生物谷推荐全文下载：基于微生物的可控生物制造
更多全文请查看链接：http://journals.im.ac.cn
声明：本文由《微生物学报》授权生物谷 www.bioon.com 网站发布，如需转载请直接与中国科学院微生物研究所期刊联合编辑部联系并支付相应费用，未经授权不得转载，若转载将付相应的法律责任。
