生物谷报道:刚刚出版的Nature以封面报道了刚刚发现在大脑内存在一条独特的星形胶质细胞区域,它内含有大量的神经干细胞,将神经干细胞从侧脑室源源不断转移至嗅球这一发现,不仅揭示了大脑内神经干细胞的大量来源,同时也证明了神经干细胞存在迁移现象。不过这些迁移的细胞的功能还不是很清楚。
In adult rodents, one region of the brain, the subventricular zone, generates thousands of neurons every day. These cells migrate to the olfactory bulb to replace interneurons there. If the adult human brain contains a similarly productive region, there could be important implications for future developments in neuroregenerative therapy. A ribbon of astrocytes with stem cell potential has now been identified along the walls of the lateral ventricle of the adult human brain. The cover shows a reconstruction of the skull and brain, based on computed tomography, indicating regions of the subventricular zone where these stem cells are found. Unlike the stem cell progeny of the rodent brain, the young human neurons do not find their way to the olfactory bulb, so their precise function is not yet clear.
Original article:(Nature全文不免费如果需要,请向我们的管理员索取,写信bioon@bioon.com)
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
NADER SANAI, ANTHONY D. TRAMONTIN, ALFREDO QUIÑONES-HINOJOSA, NICHOLAS M. BARBARO, NALIN GUPTA, SANDEEP KUNWAR, MICHAEL T. LAWTON, MICHAEL W. MCDERMOTT, ANDREW T. PARSA, JOSÉ MANUEL-GARCÍA VERDUGO, MITCHEL S. BERGER & ARTURO ALVAREZ-BUYLLA
Nature 427, 740–744 (2004); doi:10.1038/nature02301
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Neuroscience: Immigration denied
PASKO RAKIC
The adult human brain cannot replace lost neurons. This might be because it is reluctant to accept newcomers into an already established neural network, rather than because potential progenitors are absent.
Nature 427, 685–686 (2004); doi:10.1038/427685a
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