南开大学医学院病理与免疫学系，天津教育部生物活性物质重点实验室的研究者在最新一期的Cancer Research上发布研究性文章。文章的通讯作者是南开大学医学院特聘教授杨荣存博士。文章主要研究细胞因子信号转导抑制因子3（suppressor of cytokine Signaling 3，简称SOCS3）对骨髓细胞分化的调控。
在白细胞介素6，脂多糖或是肿瘤相关因子的刺激下，骨髓细胞（bone marrow cells，BMC）中的细胞因子信号转导抑制因子3的表达量会上升。尽管这一现象已经被发现，但是细胞因子信号转导抑制因子3的表达量增多对骨髓细胞的分化有什么影响，这一问题一直悬而未决。
在本研究中，杨荣存教授带领研究小组研究发现细胞因子信号转导抑制因子3的表达量上升可有效地促进骨髓细胞单向分化成为CD8 T细胞。更重要的是，肺可以成为一个无胸腺组织提供适应的场所供骨髓细胞分化成CD8+T细胞。在SOCS3促进骨髓细胞分化成CD8+ T细胞过程中，Notch1起关键的作用。因此，研究者得出结论，在某些病理条件（比如肿瘤，炎症）下，上调SOCS3的表达量可促进肺组织中的Notch1表达，最终促进骨髓细胞分化成为CD8+ T细胞。
这一结果为抗疾病尤其是抗肿瘤的理论增添了新内容。（生物谷Bioon.com）
生物谷推荐原始出处：
Cancer Research 69, 1578-1586, February 15, 2009.doi: 10.1158/0008-5472.CAN-08-2744
Suppressor of Cytokine Signaling 3 Promotes Bone Marrow Cells to Differentiate into CD8+ T Lymphocytes in Lung Tissue via Up-Regulating Notch1 Expression
Zhuohan Zhang1, Bin Zeng1, Zhiqian Zhang1, Guohui Jiao1, Haijie Li1, Zhizi Jing1, Jiangbo Ouyang1, Xin Yuan1, Limin Chai1, Yongzhe Che2, Yuan Zhang1 and Rongcun Yang1,3
Departments of 1 Immunology and 2 Pathology, Nankai University School of Medicine; 3 Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, People's Republic of China
Suppressor of cytokine signaling 3 (SOCS3) expression in bone marrow cells (BMC) was up-regulated upon exposure to interleukin 6, lipopolysaccharide, or tumor-associated factors. But, how the up-regulated SOCS3 affects differentiation of BMCs is incompletely characterized. Here, we showed that SOCS3 promoted BMCs to intently differentiate into CD8 T cells. Importantly, lung can be as one athymus tissue for the BMCs to differentiate into CD8+ T cells. Notch1 plays a critical role in the differentiation from SOCS3-transfected BMCs to CD8+ T cells. We conclude that the up-regulated SOCS3 in some pathologic conditions, such as tumor and inflammation, might promote BMCs to differentiate into CD8+ T lymphocytes in lung tissue via up-regulating Notch1 expression. This may represent a new mechanism against diseases such as tumor.
