2010年2月18日，北京生命科学研究所周俭民实验室在Cell Host & Microbe杂志在线发表文章报道了 (Pseudomonas syringae)效应蛋白AvrB干扰植物激素信号途径的分子机理。
效应蛋白AvrB可以诱导激素茉莉酸(Jasmonic acid)信号途径的基因表达，增加植物对丁香假单胞菌的感病性。该工作发现，在拟南芥中AvrB的这些功能依赖于MAP kinase 4 (MPK4)、HSP90分子伴侣复合体以及AvrB互作蛋白RIN4。AvrB与HSP90蛋白复合体、MPK4互作，诱导了MPK4的磷素化。RIN4可能作用与MPK4的下游，是茉莉酸信号途径的一个正调控因子。这些发现揭示了AvrB干扰植物激素，促进植物感病的一个新的信号通路。（生物谷Bioon.com）
生物谷推荐原始出处：
Cell Host & Microbe, Volume 7, Issue 2, 164-175, 18 February 2010 DOI:10.1016/j.chom.2010.01.009
Pseudomonas syringae Effector Protein AvrB Perturbs Arabidopsis Hormone Signaling by Activating MAP Kinase 4
Haitao Cui, Yujing Wang, Li Xue, Jinfang Chu, Cunyu Yan, Jihong Fu, Mingsheng Chen, Roger W. Innes, Jian-Min Zhou
Pathogenic microbes often modulate phytohormone physiology in the host to their advantage. We previously showed that the Pseudomonas syringae effector protein AvrB perturbs hormone signaling, as exemplified by upregulated expression of jasmonic acid response genes, and enhances plant susceptibility. Here we show that these effects of AvrB require the Arabidopsis mitogen-activated protein kinase MAP kinase 4 (MPK4), HSP90 chaperone components, and the AvrB-interacting protein, RIN4. AvrB interacts with MPK4 and the HSP90 chaperone, and AvrB induces MPK4 activation in a manner promoted by HSP90; RIN4 likely acts downstream of MPK4. These findings link Arabidopsis proteins MPK4, HSP90, and RIN4 into a pathway that P. syringae AvrB activates for the benefit of the bacterium, perturbing hormone signaling and enhancing plant susceptibility.
