据外媒报道，美国科学家利用生物干细胞技术，利用两只公鼠培养出“后代”。这一实验的成功将有助于保护濒危物种，甚至可以帮助同性伴侣拥有属于双方的孩子。
Biology of Reproduction 在12月8日刊发的文章称，美国德得克萨斯州安德森癌症中心的科学家从一个公鼠(XY)胎儿的干细胞中，制造出一个诱导多能干细胞系(IPS)。
这些诱导多能干细胞是由成熟的干细胞经历基因重组，形成类似胚胎干细胞的状态。
这些诱导多能干细胞中的一些在成长过程中，自行失去了Y染色体，转变成XO细胞。
这些XO细胞之后被注入老鼠胚胎内，再移植到代孕母鼠体内，生产出携带原来公鼠身上的X染色体子鼠。
之后，这些新生的小老鼠中的母鼠跟正常的公鼠交配，它们的孩子、无论公鼠还是母鼠，都会同时携带两个“父亲”的基因。
研究者们还称，通过这一技术，也可以生产出含有两个母鼠基因的子鼠。
然而，这项研究中还介绍，这一技术用在人身上还需要很长的时间。
目前，对于人类的诱导突变干细胞的利用还受到严格限制。（生物谷Bioon.com）
生物谷推荐原文出处：
Biology of Reproduction doi: 10.1095/biolreprod.110.088831
Generation of Viable Male and Female Mice from Two Fathers
Jian Min Deng, Kei Satoh, Hao Chang, Zhaoping Zhang, M. David Stewart, Hongran Wang, Austin J. Cooney and Richard R. Behringer
Abstract
In sexual species, fertilization of oocytes produces individuals with alleles derived from both parents. Here we use pluripotent stem cells derived from somatic cells to combine the haploid genomes from two males to produce viable sons and daughters. Male (XY) mouse induced pluripotent stem (iPS) cells (Father #1) were used to isolate subclones that had spontaneously lost the Y chromosome to become genetically female (XO). These male-derived XO stem cells were used to generate female chimeras that were bred with genetically distinct males (Father #2), yielding progeny possessing genetic information that was equally derived from both fathers. Thus, functional oocytes can be generated from male somatic cells after reprogramming and spontaneous sex reversal. These findings have novel implications for mammalian reproduction and assisted reproductive technology.
